{"id":"e63f229e-96c2-560e-810c-580e0c366cba","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:poly-gamma-glutamate-is-the-identified-allergen-in-natto-allergy","predicate":"causes","statement":"All thirteen patients with natto allergy in an allergy-clinic cohort had positive skin prick and basophil activation tests to poly-gamma-glutamic acid.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ba6c01aa-8972-5ee9-966c-21d1cae42948","mechanism_event_label":"All thirteen patients with natto allergy in an allergy-clinic cohort had positive skin prick and basophil activation tests to poly-gamma-glutamic acid.","subject":{"id":"4ded1eff-123c-5b18-b5d2-f206c3169a86","slug":"poly-gamma-glutamate","display_name":"Poly-gamma-glutamic acid","entity_type_key":"chemical_species"},"object":{"id":"028309ed-7252-52e7-9e27-c6f5d8b9c3a8","slug":"poly-gamma-glutamate-sensitization","display_name":"Sensitization to poly-gamma-glutamic acid","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ba6c01aa-8972-5ee9-966c-21d1cae42948","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:poly-gamma-glutamate-is-the-identified-allergen-in-natto-allergy-event","event_type":"observed_intervention","label":"All thirteen patients with natto allergy in an allergy-clinic cohort had positive skin prick and basophil activation tests to poly-gamma-glutamic acid.","description":"Skin prick and basophil activation testing","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4ded1eff-123c-5b18-b5d2-f206c3169a86","slug":"poly-gamma-glutamate","display_name":"Poly-gamma-glutamic acid","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"028309ed-7252-52e7-9e27-c6f5d8b9c3a8","slug":"poly-gamma-glutamate-sensitization","display_name":"Sensitization to poly-gamma-glutamic acid","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Cross-sectional questionnaire and testing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (140 food-allergy outpatients, 13 with natto allergy)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Natto food","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Poly-gamma-glutamate causes late-onset anaphylaxis to natto. The sensitizing exposure this study identified was marine sports, especially surfing, at an odds ratio of 278, and not natto consumption: there was no significant relation between the amount of natto eaten and sensitization. The finding is about natto the food, and does not establish whether any given purified supplement contains poly-gamma-glutamate, residual soy protein or neither.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (140 food-allergy outpatients, 13 with natto allergy)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"All thirteen patients with natto allergy in an allergy-clinic cohort had positive skin prick and basophil activation tests to poly-gamma-glutamic acid.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Surfing as a risk factor for sensitization to poly(γ-glutamic acid) in fermented soybeans, natto, allergy. (2018) https://pubmed.ncbi.nlm.nih.gov/29175280/ DOI: 10.1016/j.alit.2017.11.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo, oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Skin prick and basophil activation testing","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7f67393d-8148-5d50-bb61-b056fea880d3","evidence_kind":"source_excerpt","locator":"Lines 1412-1412","start_line":1412,"end_line":1412,"excerpt":"All thirteen patients with natto allergy in an allergy-clinic cohort had positive skin prick and basophil activation tests to poly-gamma-glutamic acid.","model_system":"Human (140 food-allergy outpatients, 13 with natto allergy)","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}