{"id":"e638a75b-3cc2-5ec7-b733-73432d6c7054","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:transformation-scope-z-ajoene","predicate":"has_distinct_preparation_related_product","statement":"Allicin transformation and garlic processing involve chemically distinct z-ajoene; this provenance does not transfer the product's effects to allicin.","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"743bdfec-10e5-5afb-a520-002f767515e0","mechanism_event_label":"Allicin transformation and garlic processing involve chemically distinct z-ajoene; this provenance does not transfer the product's effects to allicin.","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"1b776063-3bc6-5d04-adaf-970a51bc165b","slug":"z-ajoene","display_name":"Z-Ajoene","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"743bdfec-10e5-5afb-a520-002f767515e0","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:transformation-scope-z-ajoene-event","event_type":"chemical_preparation_provenance","label":"Allicin transformation and garlic processing involve chemically distinct z-ajoene; this provenance does not transfer the product's effects to allicin.","description":"**Distinct sulfur compounds.** Alliin, allicin, diallyl disulfide (DADS), diallyl trisulfide (DATS), E-ajoene, Z-ajoene, and the two vinyldithiin isomers require separate records. Preparation conditions influence the transformation products and ajoene isomer ratio. S-allylcysteine (SAC) has a thioether linkage; S-allylmercaptocysteine (SAMC) is a mixed disulfide. SAMC can arise by reaction with cysteine, whereas SAC is not another name for allicin. Food processing products, biological reaction products, and metabolites should not be collapsed into one chemical family that inherits every member's effects. [Iberl 1990](https://pubmed.ncbi.nlm.nih.gov/17221396/) [Rabinkov 1998](https://pubmed.ncbi.nlm.nih.gov/9528659/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"1b776063-3bc6-5d04-adaf-970a51bc165b","slug":"z-ajoene","display_name":"Z-Ajoene","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Chemical preparation/transformation scope; media determine product mixture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"DADS/DATS and ajoene remain distinct. This qualitative preparation relationship does not establish human metabolic yield or tissue exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Allicin transformation and garlic processing involve chemically distinct z-ajoene; this provenance does not transfer the product's effects to allicin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Products of Allicin Transformation: Ajoenes and Dithiins, Characterization and their Determination by HPLC*. | 1990 | DOI 10.1055/s-2006-960926 | PMID 17221396 | https://pubmed.ncbi.nlm.nih.gov/17221396/ | https://doi.org/10.1055/s-2006-960926","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 15-15; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e4e36c8c-89f1-5668-86bf-c2b82d815db2","evidence_kind":"source_excerpt","locator":"Lines 15-15","start_line":15,"end_line":15,"excerpt":"**Distinct sulfur compounds.** Alliin, allicin, diallyl disulfide (DADS), diallyl trisulfide (DATS), E-ajoene, Z-ajoene, and the two vinyldithiin isomers require separate records. Preparation conditions influence the transformation products and ajoene isomer ratio. S-allylcysteine (SAC) has a thioether linkage; S-allylmercaptocysteine (SAMC) is a mixed disulfide. SAMC can arise by reaction with cysteine, whereas SAC is not another name for allicin. Food processing products, biological reaction products, and metabolites should not be collapsed into one chemical family that inherits every member's effects. [Iberl 1990](https://pubmed.ncbi.nlm.nih.gov/17221396/) [Rabinkov 1998](https://pubmed.ncbi.nlm.nih.gov/9528659/)","model_system":"Chemical preparation/transformation scope; media determine product mixture.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}