{"id":"e62ae8ff-e063-5865-b5d9-6b2a8d81f3e3","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-sglt2-urine","predicate":"loss_of_function_increases","statement":"Sglt2-null mice had glucosuria and polyuria without differences in plasma glucose or GFR versus controls.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a5190ead-b304-52b3-b4e1-543b2204467d","mechanism_event_label":"Losing this transporter sends glucose into urine; it does not mean the blood glucose must be high.","subject":{"id":"c19dc82c-da63-5076-96f1-4e89035e8510","slug":"mouse-slc5a2","display_name":"Mouse sodium/glucose cotransporter SGLT2 / Slc5a2","entity_type_key":"protein"},"object":{"id":"3aa8a0db-7fcc-5d1b-8a4b-fcb0bacb601c","slug":"urinary-glucose-excretion","display_name":"Urinary glucose excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a5190ead-b304-52b3-b4e1-543b2204467d","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-sglt2-urine-event","event_type":"biochemical_relationship","label":"Losing this transporter sends glucose into urine; it does not mean the blood glucose must be high.","description":"Sglt2-null mice had glucosuria and polyuria without differences in plasma glucose or GFR versus controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c19dc82c-da63-5076-96f1-4e89035e8510","slug":"mouse-slc5a2","display_name":"Mouse sodium/glucose cotransporter SGLT2 / Slc5a2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3aa8a0db-7fcc-5d1b-8a4b-fcb0bacb601c","slug":"urinary-glucose-excretion","display_name":"Urinary glucose excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/20616166.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0596ceea07c063931780bf6128a238c81622461ed65dd5b0d382f0202e1626f9\", \"start_char\": 0, \"end_char\": 1704, \"text_sha256\": \"0596ceea07c063931780bf6128a238c81622461ed65dd5b0d382f0202e1626f9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sglt2-null mice, localization, clearance and micropuncture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Genetic Slc5a2 deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Renal glucose reabsorption and water output changed, but the knockout did not show the measured signs of volume depletion. Genetic deletion is not a dietary experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Losing this transporter sends glucose into urine; it does not mean the blood glucose must be high.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p20616166] SGLT2 mediates glucose reabsorption in the early proximal tubule. (2011). https://pubmed.ncbi.nlm.nih.gov/20616166/ DOI: 10.1681/asn.2010030246","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Renal early proximal tubule","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5ca70759-2f05-5453-8b28-6101410c387b","evidence_kind":"source_excerpt","locator":"Lines 330-341","start_line":330,"end_line":341,"excerpt":"### sodium-sglt2-urine\nSglt2-null mice had glucosuria and polyuria without differences in plasma glucose or GFR versus controls.\nCondition category: machinery_impairment\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Losing this transporter sends glucose into urine; it does not mean the blood glucose must be high.\norganism: Mouse\ntissue_or_cell_type: Renal early proximal tubule\nexperimental_model: Sglt2-null mice, localization, clearance and micropuncture\nlimitations: Renal glucose reabsorption and water output changed, but the knockout did not show the measured signs of volume depletion. Genetic deletion is not a dietary experiment.\nexposure: Genetic Slc5a2 deletion\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/20616166.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0596ceea07c063931780bf6128a238c81622461ed65dd5b0d382f0202e1626f9\", \"start_char\": 0, \"end_char\": 1704, \"text_sha256\": \"0596ceea07c063931780bf6128a238c81622461ed65dd5b0d382f0202e1626f9\"}\n[sodium-p20616166] SGLT2 mediates glucose reabsorption in the early proximal tubule. (2011). https://pubmed.ncbi.nlm.nih.gov/20616166/ DOI: 10.1681/asn.2010030246","model_system":"Sglt2-null mice, localization, clearance and micropuncture","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p20616166] SGLT2 mediates glucose reabsorption in the early proximal tubule. 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