{"id":"e61faeb6-ce18-5b33-91e6-afa44880e7ae","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-catalase","predicate":"increases","statement":"Astaxanthin increased PPAR-gamma and catalase expression in challenged AGS cells; the PPAR-gamma antagonist GW9662 suppressed the ROS/IL-8 protective response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fc0f5e33-a21f-52c5-91c9-15adb4e5bef0","mechanism_event_label":"A receptor-linked antioxidant enzyme response contributed in this model.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"a95fd25e-3d30-5ece-a735-74ab7fede31f","slug":"human-cat","display_name":"Human catalase / CAT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"fc0f5e33-a21f-52c5-91c9-15adb4e5bef0","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-gastric-catalase-event","event_type":"observed_relationship","label":"A receptor-linked antioxidant enzyme response contributed in this model.","description":"Astaxanthin increased PPAR-gamma and catalase expression in challenged AGS cells; the PPAR-gamma antagonist GW9662 suppressed the ROS/IL-8 protective response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a95fd25e-3d30-5ece-a735-74ab7fede31f","slug":"human-cat","display_name":"Human catalase / CAT","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7f456e18-fabc-532d-bbfe-cd3a8cf1b348","slug":"pparg","display_name":"Human PPAR gamma / PPARG","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5dd031e8-9ede-5db7-a4e1-961de31f0b49","slug":"cxcl8","display_name":"Human interleukin-8 / CXCL8","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human AGS expression assays and pharmacological inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Antagonist sensitivity is not direct binding evidence or a demonstration of iron deficiency rescue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A receptor-linked antioxidant enzyme response contributed in this model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"311fb33a-64e2-5b9a-a536-1d86b86d4450","evidence_kind":"source_excerpt","locator":"Lines 302-308","start_line":302,"end_line":308,"excerpt":"## astaxanthin-gastric-catalase\nA receptor-linked antioxidant enzyme response contributed in this model.\nAstaxanthin increased PPAR-gamma and catalase expression in challenged AGS cells; the PPAR-gamma antagonist GW9662 suppressed the ROS/IL-8 protective response.\nModel: Human AGS expression assays and pharmacological inhibition.\nLimitations: Antagonist sensitivity is not direct binding evidence or a demonstration of iron deficiency rescue.\nEvidence access: Primary abstract\nAstaxanthin Inhibits Mitochondrial Dysfunction and Interleukin-8 Expression in Helicobacter pylori-Infected Gastric Epithelial Cells. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30231525/ · DOI 10.3390/nu10091320","model_system":"Human AGS expression assays and pharmacological inhibition.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}