{"id":"e59e112d-93fc-5ebc-9946-cb16834fdf20","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-ineffective-erythropoiesis-iron-hypothesis","predicate":"deficiency_hypothesized_to_limit_erythroblast_iron_use","statement":"The authors proposed that ineffective erythropoiesis during cobalamin deficiency reduces iron use by erythroblasts, helping explain the before/after iron results.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9ca4e4de-e35a-5c00-ac75-567b46c2822b","mechanism_event_label":"If red-cell production is impaired, available iron and productive iron use need not move together.","subject":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"object":{"id":"84c0dc11-5e1c-52f4-a5e9-3d2f495344cf","slug":"erythroblast-iron-utilization","display_name":"Iron utilization by erythroblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9ca4e4de-e35a-5c00-ac75-567b46c2822b","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-ineffective-erythropoiesis-iron-hypothesis-event","event_type":"biochemical_relationship","label":"If red-cell production is impaired, available iron and productive iron use need not move together.","description":"The authors proposed that ineffective erythropoiesis during cobalamin deficiency reduces iron use by erythroblasts, helping explain the before/after iron results.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"connected_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"84c0dc11-5e1c-52f4-a5e9-3d2f495344cf","slug":"erythroblast-iron-utilization","display_name":"Iron utilization by erythroblasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Specific candidate mechanism connecting B12 function to iron utilization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Before/after series of 75 patients diagnosed with cobalamin deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Blood counts and iron-status measurements before and after cobalamin therapy; regimen is not extracted from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Proposed explanation, not a directly measured isotope flux or demonstrated cellular mediator in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"If red-cell production is impaired, available iron and productive iron use need not move together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b12-solmaz2015] Cobalamin deficiency can mask depleted body iron reserves (2015). https://pubmed.ncbi.nlm.nih.gov/25825568/ DOI: 10.1007/s12288-014-0417-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"92a2e60f-7bd2-51ed-b38a-cc39812f522f","evidence_kind":"source_excerpt","locator":"Lines 1611-1622","start_line":1611,"end_line":1622,"excerpt":"### b12-ineffective-erythropoiesis-iron-hypothesis\nThe authors proposed that ineffective erythropoiesis during cobalamin deficiency reduces iron use by erythroblasts, helping explain the before/after iron results.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: If red-cell production is impaired, available iron and productive iron use need not move together.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Before/after series of 75 patients diagnosed with cobalamin deficiency.\nlimitations: Proposed explanation, not a directly measured isotope flux or demonstrated cellular mediator in this study.\nexposure: Blood counts and iron-status measurements before and after cobalamin therapy; regimen is not extracted from the abstract.\ncross_nutrient: Specific candidate mechanism connecting B12 function to iron utilization.\n[b12-solmaz2015] Cobalamin deficiency can mask depleted body iron reserves (2015). https://pubmed.ncbi.nlm.nih.gov/25825568/ DOI: 10.1007/s12288-014-0417-x","model_system":"Before/after series of 75 patients diagnosed with cobalamin deficiency.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-solmaz2015] Cobalamin deficiency can mask depleted body iron reserves (2015). https://pubmed.ncbi.nlm.nih.gov/25825568/ DOI: 10.1007/s12288-014-0417-x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}