{"id":"e5914ae4-7dab-5866-8173-a0a4dfb0b4e1","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-gsh","predicate":"supports_oxidation","statement":"Iodide substituted for thiocyanate in LPO/H2O2-dependent glutathione oxidation; chloride and bromide were ineffective substitutes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8b6a7b49-c663-5726-b603-5e6fb2f63de5","mechanism_event_label":"This iodine chemistry can consume glutathione in a test system.","subject":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"object":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8b6a7b49-c663-5726-b603-5e6fb2f63de5","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-gsh-event","event_type":"observed_relationship","label":"This iodine chemistry can consume glutathione in a test system.","description":"Iodide substituted for thiocyanate in LPO/H2O2-dependent glutathione oxidation; chloride and bromide were ineffective substitutes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3d671567-4fb6-5b5f-a328-156987d5b396","slug":"lactoperoxidase-family","display_name":"Lactoperoxidase enzyme family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5d54e0a3-869f-5132-82c9-4c0ff47cd400","slug":"thiocyanate-ion","display_name":"Thiocyanate ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Purified biochemical reaction; GSH measured by amperometric titration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No demonstration that ordinary KI intake depletes human glutathione.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"This iodine chemistry can consume glutathione in a test system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Free radical generation and coupled thiol oxidation by lactoperoxidase/SCN-/H2O2. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1324202/ · DOI 10.1016/0891-5849(92)90014-8","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0b657183-985d-5a4a-87ea-ae2b5026aa58","evidence_kind":"source_excerpt","locator":"Lines 248-254","start_line":248,"end_line":254,"excerpt":"## ki-gsh\nThis iodine chemistry can consume glutathione in a test system.\nIodide substituted for thiocyanate in LPO/H2O2-dependent glutathione oxidation; chloride and bromide were ineffective substitutes.\nModel: Purified biochemical reaction; GSH measured by amperometric titration.\nLimitations: No demonstration that ordinary KI intake depletes human glutathione.\nEvidence location: Primary abstract\nFree radical generation and coupled thiol oxidation by lactoperoxidase/SCN-/H2O2. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1324202/ · DOI 10.1016/0891-5849(92)90014-8","model_system":"Purified biochemical reaction; GSH measured by amperometric titration.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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