{"id":"e575b018-df79-5c84-a7cc-822385e09718","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-mast-tnf","predicate":"reduces_release","statement":"Luteolin inhibited preformed TNF secretion from activated human LAD2 mast cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"301207b4-284b-5172-b7a6-10c66be3e4c9","mechanism_event_label":"It affected another mediator besides histamine.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"600d5b09-e092-5146-af1e-2510cf17bac6","slug":"tnf","display_name":"Tumor necrosis factor","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"301207b4-284b-5172-b7a6-10c66be3e4c9","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-mast-tnf-event","event_type":"observed_relationship","label":"It affected another mediator besides histamine.","description":"Luteolin inhibited preformed TNF secretion from activated human LAD2 mast cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"600d5b09-e092-5146-af1e-2510cf17bac6","slug":"tnf","display_name":"Tumor necrosis factor","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Substance-P or IgE/anti-IgE mast-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a clinical comparison of oral treatments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"It affected another mediator besides histamine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25498791/ · DOI 10.1016/j.jaci.2014.10.032","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"85ef270b-9f21-5b63-9fa0-c90dee358ae1","evidence_kind":"source_excerpt","locator":"Lines 396-402","start_line":396,"end_line":402,"excerpt":"## luteolin-mast-tnf\nIt affected another mediator besides histamine.\nLuteolin inhibited preformed TNF secretion from activated human LAD2 mast cells.\nModel: Substance-P or IgE/anti-IgE mast-cell experiments.\nLimitations: Not a clinical comparison of oral treatments.\nEvidence access: Primary abstract\nThe novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25498791/ · DOI 10.1016/j.jaci.2014.10.032","model_system":"Substance-P or IgE/anti-IgE mast-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}