{"id":"e522a5fb-f5e0-5aa9-a955-550379f9992f","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-cox2-dependence","predicate":"inhibition_blocks","statement":"Selective COX-2 inhibition abolished the proliferative and anti-apoptotic strontium responses in wild-type and Casr-knockout osteoblasts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"eb019b62-ca00-589d-9e5b-ee473ce28b23","mechanism_event_label":"Prostaglandin-producing machinery links the response to lipid signaling.","subject":{"id":"7d8faeac-0c6a-5d35-af89-0c883bc4185e","slug":"mouse-ptgs2","display_name":"Mouse cyclooxygenase-2 / Ptgs2","entity_type_key":"protein"},"object":{"id":"f9ae4e9e-475d-5e19-b68c-1a45c6e4b01e","slug":"mouse-strontium-osteoblast-growth-survival","display_name":"Growth and survival responses to strontium in mouse osteoblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eb019b62-ca00-589d-9e5b-ee473ce28b23","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-cox2-dependence-event","event_type":"observed_relationship","label":"Prostaglandin-producing machinery links the response to lipid signaling.","description":"Selective COX-2 inhibition abolished the proliferative and anti-apoptotic strontium responses in wild-type and Casr-knockout osteoblasts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7d8faeac-0c6a-5d35-af89-0c883bc4185e","slug":"mouse-ptgs2","display_name":"Mouse cyclooxygenase-2 / Ptgs2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f9ae4e9e-475d-5e19-b68c-1a45c6e4b01e","slug":"mouse-strontium-osteoblast-growth-survival","display_name":"Growth and survival responses to strontium in mouse osteoblasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5733d7d1-6259-588f-a4a9-4d0dc0133735","slug":"prostaglandin-e2","display_name":"Prostaglandin E2","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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