{"id":"e5136bed-ccf2-549b-b4eb-21bee746af46","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-psychosis-earlier-onset","predicate":"reduces","statement":"Cannabis use was associated with an earlier onset of psychosis in a systematic meta-analysis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e0e1b6c3-557b-5381-a1f1-d4a0760b858a","mechanism_event_label":"Among people who develop psychosis, users develop it younger.","subject":{"id":"efdbf605-8ade-57af-aa1b-7e907af2ffa5","slug":"cannabis-use","display_name":"Cannabis use","entity_type_key":"cellular_process"},"object":{"id":"b9a7595a-0d50-59a9-9820-92d89163d455","slug":"psychosis-onset-age","display_name":"Age at onset of psychosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e0e1b6c3-557b-5381-a1f1-d4a0760b858a","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-psychosis-earlier-onset-event","event_type":"observed_intervention","label":"Among people who develop psychosis, users develop it younger.","description":"Cannabis use was associated with an earlier onset of psychosis in a systematic meta-analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"efdbf605-8ade-57af-aa1b-7e907af2ffa5","slug":"cannabis-use","display_name":"Cannabis use","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b9a7595a-0d50-59a9-9820-92d89163d455","slug":"psychosis-onset-age","display_name":"Age at onset of psychosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/21300939.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"89d48d713734797db84d74790a6a0eb51c99f4a40f9d7e6b64fd57edf4c0c0f5\", \"start_char\": 0, \"end_char\": 1963, \"text_sha256\": \"89d48d713734797db84d74790a6a0eb51c99f4a40f9d7e6b64fd57edf4c0c0f5\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Systematic meta-analysis of age at onset of psychosis in cannabis users","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cannabis use against age at psychosis onset","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measures timing rather than incidence. 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Earlier onset in users is consistent with precipitation, with confounding, or with both.\nexposure: Cannabis use against age at psychosis onset\nevidence_span: {\"source_cache\": \"artifacts/thc-research/21300939.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"89d48d713734797db84d74790a6a0eb51c99f4a40f9d7e6b64fd57edf4c0c0f5\", \"start_char\": 0, \"end_char\": 1963, \"text_sha256\": \"89d48d713734797db84d74790a6a0eb51c99f4a40f9d7e6b64fd57edf4c0c0f5\"}\n[thc-p21300939] Cannabis use and earlier onset of psychosis: a systematic meta-analysis. (2011). https://pubmed.ncbi.nlm.nih.gov/21300939/ DOI: 10.1001/archgenpsychiatry.2011.5","model_system":"Systematic meta-analysis of age at onset of psychosis in cannabis users","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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