{"id":"e4ed61a0-0aa7-576a-a979-082eb7fa4f6a","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-extract-cyp1a2","predicate":"inhibits_tested","statement":"The three 2012 red yeast rice product extracts inhibited human microsomal CYP1A2 more potently than pure lovastatin at matched nominal lovastatin concentrations.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4967c62e-035c-597d-9ee3-932cce444198","mechanism_event_label":"The mixture changed an enzyme assay beyond its lovastatin content.","subject":{"id":"479f127b-18e1-54db-b4d0-720ceaa77e28","slug":"ryr-methanol-extract-panel-2012","display_name":"LipoCol Forte, Xuezhikang and Cholestin extract panel studied in 2012","entity_type_key":"chemical_species"},"object":{"id":"9b15c13c-a369-5d10-a76a-525e8b19221d","slug":"cyp1a2","display_name":"Human cytochrome P450 1A2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"4967c62e-035c-597d-9ee3-932cce444198","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-extract-cyp1a2-event","event_type":"observed_relationship","label":"The mixture changed an enzyme assay beyond its lovastatin content.","description":"The three 2012 red yeast rice product extracts inhibited human microsomal CYP1A2 more potently than pure lovastatin at matched nominal lovastatin concentrations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"479f127b-18e1-54db-b4d0-720ceaa77e28","slug":"ryr-methanol-extract-panel-2012","display_name":"LipoCol Forte, Xuezhikang and Cholestin extract panel studied in 2012","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9b15c13c-a369-5d10-a76a-525e8b19221d","slug":"cyp1a2","display_name":"Human cytochrome P450 1A2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text PMC3513969, CYP methods and results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human liver microsomes; product concentrations normalized to 0.5–25 micromolar lovastatin, with an NADPH-generating system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"In-vitro inhibition is not a measured interaction with every drug using this enzyme; the additional responsible constituent was not identified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The mixture changed an enzyme assay beyond its lovastatin content.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b3259c36-6b3e-57c9-928e-36da09a9bd25","evidence_kind":"source_excerpt","locator":"Lines 108-114","start_line":108,"end_line":114,"excerpt":"## red-yeast-rice-extract-cyp1a2\nThe mixture changed an enzyme assay beyond its lovastatin content.\nThe three 2012 red yeast rice product extracts inhibited human microsomal CYP1A2 more potently than pure lovastatin at matched nominal lovastatin concentrations.\nModel: Human liver microsomes; product concentrations normalized to 0.5–25 micromolar lovastatin, with an NADPH-generating system.\nLimitations: In-vitro inhibition is not a measured interaction with every drug using this enzyme; the additional responsible constituent was not identified.\nEvidence access: Primary full text PMC3513969, CYP methods and results\n[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","model_system":"Human liver microsomes; product concentrations normalized to 0.5–25 micromolar lovastatin, with an NADPH-generating system.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}