{"id":"e4dc8570-ad43-539e-8105-d8f1a3434933","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-parenteral-glucose-1979","predicate":"supplementation_followed_by_improvement_in","statement":"Chromium addition was followed by improved glucose tolerance, reduced insulin requirements, weight gain and disappearance of a confusional state in the 1979 case.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7242a006-0d33-5e99-b854-4848277df3a2","mechanism_event_label":"A second historical case reported improvement, while the cause and broader applicability remain uncertain.","subject":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"object":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7242a006-0d33-5e99-b854-4848277df3a2","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-parenteral-glucose-1979-event","event_type":"observed_intervention","label":"A second historical case reported improvement, while the cause and broader applicability remain uncertain.","description":"Chromium addition was followed by improved glucose tolerance, reduced insulin requirements, weight gain and disappearance of a confusional state in the 1979 case.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/104057.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"858c83b6633bd3a8c4efd76fa98e12e487db932eda817827319066281fbcd6da\", \"start_char\": 0, \"end_char\": 655, \"text_sha256\": \"858c83b6633bd3a8c4efd76fa98e12e487db932eda817827319066281fbcd6da\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical post-bowel-resection parenteral-nutrition case report","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Five months parenteral nutrition; 150 µg chromium/day supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled case, with serum chromium described as at the low end of the then-normal range. No validated modern deficiency threshold or molecular mediator established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human patient","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A second historical case reported improvement, while the cause and broader applicability remain uncertain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p104057] Chromium deficiency during total parenteral nutrition. (1979). https://pubmed.ncbi.nlm.nih.gov/104057/ DOI: 10.1001/jama.1979.03290310036012","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Glucose regulation, weight and neurological state","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c8c56699-e446-56a7-b80b-befc170a97c5","evidence_kind":"source_excerpt","locator":"Lines 913-924","start_line":913,"end_line":924,"excerpt":"### chromium-parenteral-glucose-1979\nChromium addition was followed by improved glucose tolerance, reduced insulin requirements, weight gain and disappearance of a confusional state in the 1979 case.\nCondition category: nutrient_deficiency\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A second historical case reported improvement, while the cause and broader applicability remain uncertain.\norganism: Human patient\ntissue_or_cell_type: Glucose regulation, weight and neurological state\nexperimental_model: Historical post-bowel-resection parenteral-nutrition case report\nlimitations: Uncontrolled case, with serum chromium described as at the low end of the then-normal range. No validated modern deficiency threshold or molecular mediator established.\nexposure: Five months parenteral nutrition; 150 µg chromium/day supplementation\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/104057.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"858c83b6633bd3a8c4efd76fa98e12e487db932eda817827319066281fbcd6da\", \"start_char\": 0, \"end_char\": 655, \"text_sha256\": \"858c83b6633bd3a8c4efd76fa98e12e487db932eda817827319066281fbcd6da\"}\n[chromium-p104057] Chromium deficiency during total parenteral nutrition. (1979). https://pubmed.ncbi.nlm.nih.gov/104057/ DOI: 10.1001/jama.1979.03290310036012","model_system":"Historical post-bowel-resection parenteral-nutrition case report","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chromium-p104057] Chromium deficiency during total parenteral nutrition. (1979). https://pubmed.ncbi.nlm.nih.gov/104057/ DOI: 10.1001/jama.1979.03290310036012","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa96342a-ca01-5425-98d9-d50e29bf0abd","stable_key":"import-4d8e4781-3878-5818-8d0a-7dbd6e024555","title":"Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"6cae22f9104c6de041b25c23b0fd2884cc57707ac0c9a87c20b0e665d16de5ab","revision_id":"22893798-8329-5295-9c9d-82169032fc79","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}