{"id":"e4d37856-59dd-54d9-8e4c-93701a364656","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-locomotion","predicate":"required_for_caffeine_response","statement":"Injected caffeine increased locomotion only in mice expressing A2A receptors; ingestion also produced an A2A-dependent increase in males.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"26856dd9-0a49-5832-8415-69242bc72e2e","mechanism_event_label":"The activity response depended on this receptor in the mouse experiment.","subject":{"id":"b59d4a38-8a86-5e68-9e39-9325d53cde5b","slug":"mouse-adora2a","display_name":"Mouse adenosine A2A receptor / Adora2a","entity_type_key":"protein"},"object":{"id":"d70750a8-847c-5d0f-9b39-cec4e1fd586a","slug":"mouse-locomotor-activity","display_name":"Locomotor activity in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"26856dd9-0a49-5832-8415-69242bc72e2e","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-locomotion-event","event_type":"observed_relationship","label":"The activity response depended on this receptor in the mouse experiment.","description":"Injected caffeine increased locomotion only in mice expressing A2A receptors; ingestion also produced an A2A-dependent increase in males.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b59d4a38-8a86-5e68-9e39-9325d53cde5b","slug":"mouse-adora2a","display_name":"Mouse adenosine A2A receptor / Adora2a","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d70750a8-847c-5d0f-9b39-cec4e1fd586a","slug":"mouse-locomotor-activity","display_name":"Locomotor activity in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Awake receptor-knockout mice; telemetry and respirometry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sex and route mattered; locomotion is not a direct measure of human focus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The activity response depended on this receptor in the mouse experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19218506/ · DOI 10.1152/ajpheart.00754.2008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0fca3e72-2220-5433-8c3b-758723f369b1","evidence_kind":"source_excerpt","locator":"Lines 44-50","start_line":44,"end_line":50,"excerpt":"## caf-locomotion\nThe activity response depended on this receptor in the mouse experiment.\nInjected caffeine increased locomotion only in mice expressing A2A receptors; ingestion also produced an A2A-dependent increase in males.\nModel: Awake receptor-knockout mice; telemetry and respirometry.\nLimitations: Sex and route mattered; locomotion is not a direct measure of human focus.\nEvidence access: Primary abstract\nPhysiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19218506/ · DOI 10.1152/ajpheart.00754.2008","model_system":"Awake receptor-knockout mice; telemetry and respirometry.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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