{"id":"e4d1f32a-9dd8-5402-a1b3-863e824b8143","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-fed-remethylation-preserved","predicate":"restriction_did_not_change_group_mean","statement":"Mean postprandial homocysteine remethylation did not significantly change after restriction, with substantial individual variation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7950cbee-b2ba-5e03-95f1-aa01700cf6f0","mechanism_event_label":"Lower B6 did not make this measured process uniformly fail.","subject":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"object":{"id":"a20b9a3a-afdc-5591-b23d-60f99eb15ae3","slug":"homocysteine-remethylation-flux","display_name":"Homocysteine remethylation flux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7950cbee-b2ba-5e03-95f1-aa01700cf6f0","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-fed-remethylation-preserved-event","event_type":"observed_intervention","label":"Lower B6 did not make this measured process uniformly fail.","description":"Mean postprandial homocysteine remethylation did not significantly change after restriction, with substantial individual variation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"pathway_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"pathway_metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c0beb226-8842-501f-a147-cac0d9fa7060","slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a20b9a3a-afdc-5591-b23d-60f99eb15ae3","slug":"homocysteine-remethylation-flux","display_name":"Homocysteine remethylation flux","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"B6 intersects methionine/folate metabolism; this experiment does not establish B12 or folate depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine healthy adults (five women, four men; ages 20–35), repeated postprandial isotope kinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"28 days dietary B6 restriction; plasma PLP49±4 to 19±2 nmol/L.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Null group means do not establish identical responses or preserved DNA methylation in every tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lower B6 did not make this measured process uniformly fail.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-lamers2011] Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women (2011). https://pubmed.ncbi.nlm.nih.gov/21430249/ DOI: 10.3945/jn.110.134197","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood and whole-body measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"4a86b60f-aa1d-5a49-8cee-e03e7748ef2d","evidence_kind":"source_excerpt","locator":"Lines 1346-1357","start_line":1346,"end_line":1357,"excerpt":"### b6-fed-remethylation-preserved\nMean postprandial homocysteine remethylation did not significantly change after restriction, with substantial individual variation.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Lower B6 did not make this measured process uniformly fail.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood and whole-body measurements\nexperimental_model: Nine healthy adults (five women, four men; ages 20–35), repeated postprandial isotope kinetics.\nlimitations: Null group means do not establish identical responses or preserved DNA methylation in every tissue.\nexposure: 28 days dietary B6 restriction; plasma PLP49±4 to 19±2 nmol/L.\ncross_nutrient: B6 intersects methionine/folate metabolism; this experiment does not establish B12 or folate depletion.\n[b6-lamers2011] Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women (2011). https://pubmed.ncbi.nlm.nih.gov/21430249/ DOI: 10.3945/jn.110.134197","model_system":"Nine healthy adults (five women, four men; ages 20–35), repeated postprandial isotope kinetics.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-lamers2011] Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women (2011). https://pubmed.ncbi.nlm.nih.gov/21430249/ DOI: 10.3945/jn.110.134197","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}