{"id":"e4abcf5c-6e31-5fa1-a6f3-23ce9a0d9378","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-mouse-brain-entry","predicate":"reaches","statement":"The mouse study reported brain entry of dietary spermidine and increased hippocampal eIF5A hypusination.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8fdffe7e-c5eb-5050-be11-088fe14aa6a0","mechanism_event_label":"Brain delivery was tested in mice.","subject":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"object":{"id":"98a37723-4f57-562d-a3ee-2a5b4ae246cc","slug":"mouse-brain-spermidine-exposure","display_name":"Mouse brain spermidine exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8fdffe7e-c5eb-5050-be11-088fe14aa6a0","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-mouse-brain-entry-event","event_type":"observed_relationship","label":"Brain delivery was tested in mice.","description":"The mouse study reported brain entry of dietary spermidine and increased hippocampal eIF5A hypusination.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98a37723-4f57-562d-a3ee-2a5b4ae246cc","slug":"mouse-brain-spermidine-exposure","display_name":"Mouse brain spermidine exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse exposure and hippocampal measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer the same human brain exposure from a plasma measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Brain delivery was tested in mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary spermidine improves cognitive function. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33852843/ · DOI 10.1016/j.celrep.2021.108985","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fc490b73-5b87-555c-8938-06582b88324f","evidence_kind":"source_excerpt","locator":"Lines 350-356","start_line":350,"end_line":356,"excerpt":"## spermidine-mouse-brain-entry\nBrain delivery was tested in mice.\nThe mouse study reported brain entry of dietary spermidine and increased hippocampal eIF5A hypusination.\nModel: Mouse exposure and hippocampal measurements.\nLimitations: Do not infer the same human brain exposure from a plasma measurement.\nEvidence access: Primary abstract\nDietary spermidine improves cognitive function. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33852843/ · DOI 10.1016/j.celrep.2021.108985","model_system":"Mouse exposure and hippocampal measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8eec8784bc2bd0384cfd53c6603c4ced8e53c227d9ab29ed85594c43e34c68ef","revision_id":"7c421a18-4526-59f6-b84e-4be533bc35ac","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}