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(2015). https://pubmed.ncbi.nlm.nih.gov/25712056/ DOI: 10.1158/1940-6207.capr-14-0359","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Colon epithelial cancer cells and experimental inflammatory colon tumors","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"157285e2-efcb-5bd1-9730-33ec0731deb5","evidence_kind":"source_excerpt","locator":"Lines 636-647","start_line":636,"end_line":647,"excerpt":"### ceylon-mouse-colon\nDietary cinnamaldehyde suppressed AOM/DSS-associated colon carcinogenesis in Nrf2-intact mice.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The treated wild-type mice developed less experimental colon cancer.\norganism: Mouse\ntissue_or_cell_type: Colon epithelial cancer cells and experimental inflammatory colon tumors\nexperimental_model: HCT116 mechanism and AOM/DSS knockout-mouse experiment\nlimitations: No human cancer-prevention outcome; the abstract identifies C151 dependence but does not resolve the transfected KEAP1 construct species.\nexposure: Purified cinnamaldehyde cell exposure and dietary supplementation in mice\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/25712056.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8ad37b0dca440e7fa609a46cf02377c2979d2be8e09291a370efb963ff3c9cfd\", \"start_char\": 0, \"end_char\": 1920, \"text_sha256\": \"8ad37b0dca440e7fa609a46cf02377c2979d2be8e09291a370efb963ff3c9cfd\"}\n[ceylon-p25712056] Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. 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