{"id":"e48d20ba-185d-5914-b60b-9629ea10a049","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-turnover","predicate":"reduces","statement":"Five kinetic studies also required slower serum hormone disappearance to fit lithium-associated observations.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a3af09e2-2b7d-5b23-b88b-fd155dd3cefa","mechanism_event_label":"Blood hormone concentration reflects both release and removal.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"012cc96a-7ddf-53ab-b9b2-627eadc1de69","slug":"human-serum-thyroid-hormone-disappearance","display_name":"Human serum thyroid-hormone disappearance rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a3af09e2-2b7d-5b23-b88b-fd155dd3cefa","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-turnover-event","event_type":"observed_relationship","label":"Blood hormone concentration reflects both release and removal.","description":"Five kinetic studies also required slower serum hormone disappearance to fit lithium-associated observations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"012cc96a-7ddf-53ab-b9b2-627eadc1de69","slug":"human-serum-thyroid-hormone-disappearance","display_name":"Human serum thyroid-hormone disappearance rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human radioiodine compartment modeling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not demonstrated inhibition of a particular deiodinase; do not infer selenium depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Blood hormone concentration reflects both release and removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The use of lithium in the treatment of thyrotoxicosis. · 1972 · https://pubmed.ncbi.nlm.nih.gov/4115707/ · DOI 10.1172/JCI107094","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2cd417cf-b72d-5e8b-9da5-9625976b759f","evidence_kind":"source_excerpt","locator":"Lines 400-406","start_line":400,"end_line":406,"excerpt":"## lithium-thyroid-turnover\nBlood hormone concentration reflects both release and removal.\nFive kinetic studies also required slower serum hormone disappearance to fit lithium-associated observations.\nModel: Human radioiodine compartment modeling.\nLimitations: Not demonstrated inhibition of a particular deiodinase; do not infer selenium depletion.\nEvidence access: Primary abstract\nThe use of lithium in the treatment of thyrotoxicosis. · 1972 · https://pubmed.ncbi.nlm.nih.gov/4115707/ · DOI 10.1172/JCI107094","model_system":"Human radioiodine compartment modeling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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