{"id":"e4726e5a-bc22-5977-a48f-97a20421393b","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-calcitriol-absorption","predicate":"increases","statement":"In four renal-failure patients retested after calcitriol 1 microgram/day for ten days, six-hour strontium absorption increased 4.29-fold and calcium absorption 2.4-fold.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"123a289a-0b6f-5da1-bd55-eed54467f1a2","mechanism_event_label":"Active vitamin D changed the two absorption responses by different amounts.","subject":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"object":{"id":"31bf058b-2152-5e0d-8191-acfbee9199c9","slug":"human-intestinal-strontium-absorption","display_name":"Human intestinal strontium absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"123a289a-0b6f-5da1-bd55-eed54467f1a2","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-calcitriol-absorption-event","event_type":"observed_relationship","label":"Active vitamin D changed the two absorption responses by different amounts.","description":"In four renal-failure patients retested after calcitriol 1 microgram/day for ten days, six-hour strontium absorption increased 4.29-fold and calcium absorption 2.4-fold.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"31bf058b-2152-5e0d-8191-acfbee9199c9","slug":"human-intestinal-strontium-absorption","display_name":"Human intestinal strontium absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small before/after subgroup within the dual-tracer study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Four patients, active hormone and renal impairment; not a universal effect of vitamin D3 supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Active vitamin D changed the two absorption responses by different amounts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Stable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7955914/ · DOI 10.1042/cs0870363","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"13b9152f-e325-54ea-9753-c6f783661b9f","evidence_kind":"source_excerpt","locator":"Lines 54-60","start_line":54,"end_line":60,"excerpt":"## strontium-calcitriol-absorption\nActive vitamin D changed the two absorption responses by different amounts.\nIn four renal-failure patients retested after calcitriol 1 microgram/day for ten days, six-hour strontium absorption increased 4.29-fold and calcium absorption 2.4-fold.\nModel: Small before/after subgroup within the dual-tracer study.\nLimitations: Four patients, active hormone and renal impairment; not a universal effect of vitamin D3 supplementation.\nEvidence access: Primary abstract\nStable strontium absorption as a measure of intestinal calcium absorption: comparison with the double-radiotracer calcium absorption test. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7955914/ · DOI 10.1042/cs0870363","model_system":"Small before/after subgroup within the dual-tracer study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"51221949263cdf8a22a79c32e3989599de1a37dc215700e0a076f436b40a1005","revision_id":"84f6df49-c456-5ad2-8214-cc69d5dc7722","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}