{"id":"e46bf20c-ca1c-5ce4-9aa5-ac00b4f138ba","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-depletion-th2-null","predicate":"restriction_did_not_change","statement":"Production of IL4, IL6 and IL10 was unchanged during the reported zinc-deficiency experiment, unlike the TH1-associated cytokines.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"83632db0-eb38-5abe-85df-97f77539ca3d","mechanism_event_label":"Zinc shortage did not suppress every cytokine in the same way.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"d7a7043a-6f92-54f8-b140-902a28c60a03","slug":"t-cell-il4-il6-il10-production","display_name":"T-cell IL4, IL6 and IL10 production profile","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"83632db0-eb38-5abe-85df-97f77539ca3d","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-depletion-th2-null-event","event_type":"observed_intervention","label":"Zinc shortage did not suppress every cytokine in the same way.","description":"Production of IL4, IL6 and IL10 was unchanged during the reported zinc-deficiency experiment, unlike the TH1-associated cytokines.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7c5be1b5-20ee-5921-9237-05477dc1d034","slug":"il4","display_name":"Interleukin 4","entity_type_key":"cytokine"},"role":"measured_cytokine","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"role":"measured_cytokine","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a710d887-83de-509d-b1d6-c833407656e4","slug":"il10","display_name":"Interleukin 10","entity_type_key":"cytokine"},"role":"measured_cytokine","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d7a7043a-6f92-54f8-b140-902a28c60a03","slug":"t-cell-il4-il6-il10-production","display_name":"T-cell IL4, IL6 and IL10 production profile","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Interleukin 4 (measured_cytokine); interleukin 6 (measured_cytokine); Interleukin 10 (measured_cytokine)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/beck1997.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"f731be20460b3ded18a253c1d1595c48849db9c09ef164f8a7d03a552e5619dd\", \"utf8_bytes\": 1106}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Experimental dietary zinc restriction and repletion in humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Baseline, end of zinc restriction, and following repletion were assessed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Indexed abstract only; no sample size, intake, duration, assay stimulus or repletion effect size is invented. Changes in selected cytokines do not quantify overall infection risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Zinc shortage did not suppress every cytokine in the same way.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-beck1997] Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9227444/ DOI: 10.1152/ajpendo.1997.272.6.e1002","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"T lymphocytes and cytokine production","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"7c4cb78a-08af-5adf-88a8-e91f91d8b4e7","evidence_kind":"source_excerpt","locator":"Lines 1392-1405","start_line":1392,"end_line":1405,"excerpt":"### zn-clin-depletion-th2-null\nProduction of IL4, IL6 and IL10 was unchanged during the reported zinc-deficiency experiment, unlike the TH1-associated cytokines.\nCondition category: nutrient_deficiency\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Zinc shortage did not suppress every cytokine in the same way.\norganism: Homo sapiens\ntissue_or_cell_type: T lymphocytes and cytokine production\nexperimental_model: Experimental dietary zinc restriction and repletion in humans\nlimitations: Indexed abstract only; no sample size, intake, duration, assay stimulus or repletion effect size is invented. Changes in selected cytokines do not quantify overall infection risk.\nexposure: Baseline, end of zinc restriction, and following repletion were assessed.\ncross_nutrient: Interleukin 4 (measured_cytokine); interleukin 6 (measured_cytokine); Interleukin 10 (measured_cytokine)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/beck1997.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"f731be20460b3ded18a253c1d1595c48849db9c09ef164f8a7d03a552e5619dd\", \"utf8_bytes\": 1106}\n[zn-clin-beck1997] Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. 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