{"id":"e458a9f2-2f73-5cd1-b8c2-fb936e0eaca3","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-napi2a-transcript","predicate":"low_supply_changes_transcript_abundance","statement":"Magnesium deprivation decreased renal slc34a1-mrna abundance in the 21-day rat experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"37e3416b-3cfa-543e-b01f-3a850921208d","mechanism_event_label":"The message for one phosphate-reabsorbing transporter fell.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"50e7173d-f88f-56d7-ae1d-ae8105d6ce6d","slug":"slc34a1-mrna","display_name":"SLC34A1 mRNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"37e3416b-3cfa-543e-b01f-3a850921208d","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-deficiency-napi2a-transcript-event","event_type":"biochemical_relationship","label":"The message for one phosphate-reabsorbing transporter fell.","description":"Magnesium deprivation decreased renal slc34a1-mrna abundance in the 21-day rat experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3fe4fe6-7a14-5c14-a5f8-a522fc67cdcd","slug":"slc34a1","display_name":"Sodium-phosphate cotransporter NaPi-IIa / SLC34A1","entity_type_key":"protein"},"role":"encoded_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; 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Study references: [mg-matsuzaki2013] Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats (2013). https://pubmed.ncbi.nlm.nih.gov/23816829/ DOI: 10.1684/mrh.2013.0341","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}