{"id":"e41e8936-4ad1-59df-8813-3d3411ae03de","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-dash-combination","predicate":"low_intake_with_dash_lowers","statement":"Low-sodium DASH versus high-sodium control produced mean systolic differences of 7.1 mmHg without hypertension and 11.5 mmHg with hypertension.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e2169bf0-7402-5162-a23f-60a6d9944019","mechanism_event_label":"Diet composition and sodium reduction had a combined effect.","subject":{"id":"0e4aaa90-5b94-5d69-ba79-d760da4e0268","slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2169bf0-7402-5162-a23f-60a6d9944019","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-dash-combination-event","event_type":"observed_intervention","label":"Diet composition and sodium reduction had a combined effect.","description":"Low-sodium DASH versus high-sodium control produced mean systolic differences of 7.1 mmHg without hypertension and 11.5 mmHg with hypertension.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e4aaa90-5b94-5d69-ba79-d760da4e0268","slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/11136953.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7664fc223f123220dd64755a1e9bc4ee3e9942e09b5de444bd789f210f449133\", \"start_char\": 0, \"end_char\": 1987, \"text_sha256\": \"7664fc223f123220dd64755a1e9bc4ee3e9942e09b5de444bd789f210f449133\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized controlled feeding trial in 412 participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Three sodium levels for 30 days each within assigned DASH or control diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Blood-pressure trial, not a hard-outcome trial; DASH changes multiple nutrients and foods. Its combined effect cannot be assigned to one mineral.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human adults with and without hypertension","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Diet composition and sodium reduction had a combined effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p11136953] Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. (2001). https://pubmed.ncbi.nlm.nih.gov/11136953/ DOI: 10.1056/nejm200101043440101","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic blood pressure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d6aa2a0f-1854-5ea9-9e03-2a062a146c8d","evidence_kind":"source_excerpt","locator":"Lines 1084-1095","start_line":1084,"end_line":1095,"excerpt":"### sodium-dash-combination\nLow-sodium DASH versus high-sodium control produced mean systolic differences of 7.1 mmHg without hypertension and 11.5 mmHg with hypertension.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Diet composition and sodium reduction had a combined effect.\norganism: Human adults with and without hypertension\ntissue_or_cell_type: Systemic blood pressure\nexperimental_model: Randomized controlled feeding trial in 412 participants\nlimitations: Blood-pressure trial, not a hard-outcome trial; DASH changes multiple nutrients and foods. Its combined effect cannot be assigned to one mineral.\nexposure: Three sodium levels for 30 days each within assigned DASH or control diet\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/11136953.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7664fc223f123220dd64755a1e9bc4ee3e9942e09b5de444bd789f210f449133\", \"start_char\": 0, \"end_char\": 1987, \"text_sha256\": \"7664fc223f123220dd64755a1e9bc4ee3e9942e09b5de444bd789f210f449133\"}\n[sodium-p11136953] Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. 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