{"id":"e40cf8c1-82e4-5572-b11b-d1a792e795be","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-trp-free-peptides","predicate":"dietary_removal_reduces","statement":"A tryptophan-free diet reduced small-intestinal antimicrobial peptide expression and increased chemically induced colitis susceptibility in wild-type mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d4edbf51-6c01-550e-850a-6c1dd7faa0e7","mechanism_event_label":"Low dietary supply weakened a gut defense response in mice.","subject":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"object":{"id":"eba9a619-26fc-540e-9a2d-6915c0b37e3a","slug":"mouse-trp-antimicrobial-peptides","display_name":"Mouse intestinal antimicrobial peptide expression in tryptophan experiments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d4edbf51-6c01-550e-850a-6c1dd7faa0e7","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-trp-free-peptides-event","event_type":"observed_relationship","label":"Low dietary supply weakened a gut defense response in mice.","description":"A tryptophan-free diet reduced small-intestinal antimicrobial peptide expression and increased chemically induced colitis susceptibility in wild-type mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"eba9a619-26fc-540e-9a2d-6915c0b37e3a","slug":"mouse-trp-antimicrobial-peptides","display_name":"Mouse intestinal antimicrobial peptide expression in tryptophan experiments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8cb2bb35-537a-5db0-b138-94506b1303d1","slug":"mouse-trp-colitis-susceptibility","display_name":"Mouse susceptibility to chemically induced colitis in tryptophan experiments","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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