{"id":"e3ee001f-f8fc-56c0-a6ab-18eeae316844","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-ra-tgfb-foxp3","predicate":"promotes","statement":"RA promoted regulatory T-cell differentiation under the tested TGF-beta-dependent conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ef835bb9-70e8-5f3b-a98b-7fa3d05bb2be","mechanism_event_label":"RA can cooperate with TGF-beta to favor regulatory cells.","subject":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"object":{"id":"49ab2f84-cc61-5e62-88f4-d139ea4b702a","slug":"foxp3-treg-cell","display_name":"FOXP3-positive regulatory T cell","entity_type_key":"cell_type"},"evidence_count":1,"mechanism_event":{"id":"ef835bb9-70e8-5f3b-a98b-7fa3d05bb2be","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-ra-tgfb-foxp3-event","event_type":"biochemical_relationship","label":"RA can cooperate with TGF-beta to favor regulatory cells.","description":"RA promoted regulatory T-cell differentiation under the tested TGF-beta-dependent conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"nutrient-context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"694a1fe3-07ac-5edf-a81e-96730001a3d2","slug":"tgfb1","display_name":"Transforming growth factor beta 1","entity_type_key":"cytokine"},"role":"co-signal","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"54259def-d46d-5e2f-8349-6c3e4630fb58","slug":"foxp3","display_name":"Forkhead box P3","entity_type_key":"protein"},"role":"lineage-marker","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"49ab2f84-cc61-5e62-88f4-d139ea4b702a","slug":"foxp3-treg-cell","display_name":"FOXP3-positive regulatory T cell","entity_type_key":"cell_type"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_locator","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse naive T-cell differentiation under TGF-beta and inflammatory cytokine conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Added RA in TGF-beta-driven differentiation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an unconditional anti-inflammatory effect or human dietary outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; 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topical membership is not evidence of a direct dietary effect.\nplain_language: RA can cooperate with TGF-beta to favor regulatory cells.\norganism: Mus musculus\ntissue_or_cell_type: Naive T-cell cultures\nexperimental_model: Mouse naive T-cell differentiation under TGF-beta and inflammatory cytokine conditions.\nlimitations: Not an unconditional anti-inflammatory effect or human dietary outcome.\nevidence_locator: Abstract\nexposure: Added RA in TGF-beta-driven differentiation\n[va-mucida-2007] Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid (2007). https://pubmed.ncbi.nlm.nih.gov/17569825/ DOI: 10.1126/science.1145697","model_system":"Mouse naive T-cell differentiation under TGF-beta and inflammatory cytokine conditions.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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