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(2024). https://pubmed.ncbi.nlm.nih.gov/38833370/ DOI: 10.1016/j.celrep.2024.114316","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cellular phosphate uptake/export and LAMP1-positive puncta","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f975b134-a53b-5c82-b2e6-204facdb0d99","evidence_kind":"source_excerpt","locator":"Lines 750-761","start_line":750,"end_line":761,"excerpt":"### phosphorus-ip8-export\nIn the challenge model, InsP8-dependent XPR1 regulation first adjusted phosphate efflux.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An inositol pyrophosphate signal changed phosphate export.\norganism: Human cultured HCT116, U2OS and Saos-2 systems\ntissue_or_cell_type: Cellular phosphate uptake/export and LAMP1-positive puncta\nexperimental_model: Protein interaction, localization and phosphate-challenge cell experiments\nlimitations: Temporal regulatory model in cultured cells; endogenous InsP8 signaling is not equivalent to taking an inositol or phytate supplement.\nexposure: Genetic manipulation and pharmacological mimic of phosphate homeostatic challenge\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/38833370.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5c093accfcc7194268c0fbd19d3ee39aae4206e9b2feed48b76b2a95eee33b78\", \"start_char\": 0, \"end_char\": 1103, \"text_sha256\": \"5c093accfcc7194268c0fbd19d3ee39aae4206e9b2feed48b76b2a95eee33b78\"}\n[phosphorus-p38833370] Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8. 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