{"id":"e34e4e20-e140-52e9-9c10-e5df2c9573a8","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-young-mouse-null","predicate":"did_not_improve","statement":"Fisetin did not improve the measured physical-function outcomes in young mice in the age-comparison study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"33df3563-2c49-5993-b6e6-7c4a02f6f04f","mechanism_event_label":"Benefit was not universal across age groups.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"2a7ff6f4-a893-541d-b57e-a7ee16d023b9","slug":"young-mouse-fisetin-physical-function","display_name":"Young-mouse physical-function response to fisetin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"33df3563-2c49-5993-b6e6-7c4a02f6f04f","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-young-mouse-null-event","event_type":"observed_relationship","label":"Benefit was not universal across age groups.","description":"Fisetin did not improve the measured physical-function outcomes in young mice in the age-comparison study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a7ff6f4-a893-541d-b57e-a7ee16d023b9","slug":"young-mouse-fisetin-physical-function","display_name":"Young-mouse physical-function response to fisetin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same intermittent-supplementation study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No detectable improvement in these endpoints is not proof of no biological activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Benefit was not universal across age groups.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40437670/ · DOI 10.1111/acel.70114","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9bf2c9de-eb24-5cdf-9167-645e872dfc2b","evidence_kind":"source_excerpt","locator":"Lines 240-246","start_line":240,"end_line":246,"excerpt":"## fisetin-young-mouse-null\nBenefit was not universal across age groups.\nFisetin did not improve the measured physical-function outcomes in young mice in the age-comparison study.\nModel: Same intermittent-supplementation study.\nLimitations: No detectable improvement in these endpoints is not proof of no biological activity.\nEvidence access: Primary abstract\nIntermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40437670/ · DOI 10.1111/acel.70114","model_system":"Same intermittent-supplementation study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}