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The pathway findings and treatment outcomes are retained separately. No human efficacy or dose inference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Type 2 diabetic and control mice; mouse primary-cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The receptor response reaches a transcriptional regulator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. 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The pathway findings and treatment outcomes are retained separately. No human efficacy or dose inference.\nexposure: Nasunin intervention reported; exact regimen and binding validation unavailable in the indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/41407214.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\", \"start_char\": 0, \"end_char\": 1949, \"text_sha256\": \"e0958157d5bc8c5df908b6d7ff18348c83726b06b63d2dc6953ebfd2ffdf0a08\"}\n[nasunin-p41407214] Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. 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