{"id":"e2e0ed2c-2a38-5a4d-8c06-6c9c73d6d17b","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rat-hippocampal-firing","predicate":"reduces","statement":"Local indicaxanthin application reduced spontaneous firing of rat hippocampal neurons in a dose-related manner.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"eabba34c-01f1-5d8b-a4e3-b234ffced7b9","mechanism_event_label":"Local indicaxanthin application reduced spontaneous firing of rat hippocampal neurons in a dose-related manner.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"103dcae1-abce-505c-9094-9893edccf6a7","slug":"rat-hippocampal-neuronal-firing","display_name":"Rat hippocampal neuronal firing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eabba34c-01f1-5d8b-a4e3-b234ffced7b9","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rat-hippocampal-firing-event","event_type":"observed_relationship","label":"Local indicaxanthin application reduced spontaneous firing of rat hippocampal neurons in a dose-related manner.","description":"Local indicaxanthin application reduced spontaneous firing of rat hippocampal neurons in a dose-related manner.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"103dcae1-abce-505c-9094-9893edccf6a7","slug":"rat-hippocampal-neuronal-firing","display_name":"Rat hippocampal neuronal firing","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Indicaxanthin 0.085-0.34 ng/neuron; glutamate challenge in selected recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute firing measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In vivo rat hippocampal single-neuron recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local application bypasses oral distribution. 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(2015). https://pubmed.ncbi.nlm.nih.gov/26227670/ DOI: 10.1021/acs.jafc.5b02612\nAccess: Primary PubMed abstract.","model_system":"In vivo rat hippocampal single-neuron recordings","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. 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