{"id":"e2898dd8-d80a-5c5e-9566-cf7b07ca30a0","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-triiodothyronine","predicate":"increases_in_recorded_experiment","statement":"T3 restored or stimulated thymulin production in mouse whole-thymus cultures, including a propylthiouracil-associated hypothyroid model; cycloheximide inhibited the response.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"97769c7d-9123-56f4-8b7c-56ffa69496ab","mechanism_event_label":"T3 restored or stimulated thymulin production in mouse whole-thymus cultures, including a propylthiouracil-associated hypothyroid model; cycloheximide inhibited the response.","subject":{"id":"559f37d2-ee0a-589b-8689-fa80ca9ae653","slug":"triiodothyronine","display_name":"T3","entity_type_key":"small_molecule"},"object":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"97769c7d-9123-56f4-8b7c-56ffa69496ab","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-triiodothyronine-event","event_type":"experimental_observation","label":"T3 restored or stimulated thymulin production in mouse whole-thymus cultures, including a propylthiouracil-associated hypothyroid model; cycloheximide inhibited the response.","description":"| Thyroid hormone | T3 restored/stimulated thymulin production in mouse whole-thymus cultures, including a propylthiouracil-associated hypothyroid model; inhibition by cycloheximide implicated new protein synthesis. This does not identify the peptide precursor. 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