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Recombinant enzyme in a heterologous cell line.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human enzyme","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Acetylating the second enzyme does not switch it off; it turns it into a machine that makes something else.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[asa-p8175750] Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. 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Recombinant enzyme in a heterologous cell line.\nexposure: Aspirin acetylation, with S516A, S516N, S516Q and S516M substitutions\nevidence_span: {\"source_cache\": \"artifacts/aspirin-research/8175750.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9ba85af90c62b157cf53032375ca703e8b78eff6ddd22ad627bbd7e65965d8e9\", \"start_char\": 0, \"end_char\": 1786, \"text_sha256\": \"9ba85af90c62b157cf53032375ca703e8b78eff6ddd22ad627bbd7e65965d8e9\"}\n[asa-p8175750] Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. 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