{"id":"e1e93051-05ce-5e8e-ac1e-404983e88abe","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-pth-setpoint","predicate":"shifts","statement":"Chronic lithium-treated patients required a higher calcium level for comparable PTH suppression during calcium/citrate infusions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"18bc595a-eaa2-5b46-8ccc-acbedf856fd5","mechanism_event_label":"Calcium feedback to the parathyroid gland was reset.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"1fc8c736-86a0-5106-b1b1-103102ae7f06","slug":"human-calcium-pth-set-point","display_name":"Human calcium–PTH suppression set-point","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"18bc595a-eaa2-5b46-8ccc-acbedf856fd5","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-pth-setpoint-event","event_type":"observed_relationship","label":"Calcium feedback to the parathyroid gland was reset.","description":"Chronic lithium-treated patients required a higher calcium level for comparable PTH suppression during calcium/citrate infusions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1fc8c736-86a0-5106-b1b1-103102ae7f06","slug":"human-calcium-pth-set-point","display_name":"Human calcium–PTH suppression set-point","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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