{"id":"e1a31839-4c16-599c-83ef-11bcc7e890c9","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-maternal-milk-retinol-null","predicate":"does_not_change","statement":"In a three-month cluster-randomized pilot, 20 g/day maternal Moringa leaf powder did not change human-milk vitamin A concentration or maternal and infant serum vitamin A status, although milk alpha-carotene rose modestly.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"cb363481-c22f-512d-b571-c2f6231939fd","mechanism_event_label":"In a three-month cluster-randomized pilot, 20 g/day maternal Moringa leaf powder did not change human-milk vitamin A concentration or maternal and infant serum vitamin A status, although milk alpha-carotene rose modestly.","subject":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"object":{"id":"7aa46016-8616-55ba-8234-dc4dc7f03f93","slug":"human-milk-retinol-concentration","display_name":"Human-milk retinol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cb363481-c22f-512d-b571-c2f6231939fd","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-maternal-milk-retinol-null-event","event_type":"observed_relationship","label":"In a three-month cluster-randomized pilot, 20 g/day maternal Moringa leaf powder did not change human-milk vitamin A concentration or maternal and infant serum vitamin A status, although milk alpha-carotene rose modestly.","description":"In a three-month cluster-randomized pilot, 20 g/day maternal Moringa leaf powder did not change human-milk vitamin A concentration or maternal and infant serum vitamin A status, although milk alpha-carotene rose modestly.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7aa46016-8616-55ba-8234-dc4dc7f03f93","slug":"human-milk-retinol-concentration","display_name":"Human-milk retinol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2166313e-8877-585f-8594-c8813793c5ed","slug":"rbp4","display_name":"Retinol-binding protein 4 / RBP4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Corn porridge with or without 20 g/day leaf powder","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Three months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Forty-four completing Kenyan breastfeeding mother-infant pairs","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The small pilot had baseline alpha-carotene imbalance and was not powered to establish clinical infant benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Moringa oleifera chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"moringa","display_name":"Moringa oleifera","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Forty-four completing Kenyan breastfeeding mother-infant pairs","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In a three-month cluster-randomized pilot, 20 g/day maternal Moringa leaf powder did not change human-milk vitamin A concentration or maternal and infant serum vitamin A status, although milk alpha-carotene rose modestly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Impact of Maternal Moringa oleifera Leaf Supplementation on Milk and Serum Vitamin A and Carotenoid Concentrations in a Cohort of Breastfeeding Kenyan Women and Their Infants. 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(2024). https://pubmed.ncbi.nlm.nih.gov/39408390/ DOI: 10.3390/nu16193425\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Forty-four completing Kenyan breastfeeding mother-infant pairs","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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