{"id":"e13467cf-a32e-5cfb-ad50-042cd8cee315","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-mouse-stim1","predicate":"increases_in_atrophy_model","statement":"DIM increased STIM1 expression and supported store-operated calcium entry in the experimental muscle model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b3cde3f7-8c32-545b-9c75-9a00e4ea0ad4","mechanism_event_label":"Calcium signaling is another network connection, with species kept explicit.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"1c781102-56cc-59b2-a200-295a37866f7f","slug":"mouse-stim1","display_name":"Mouse stromal interaction molecule 1 / Stim1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b3cde3f7-8c32-545b-9c75-9a00e4ea0ad4","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-mouse-stim1-event","event_type":"biochemical_relationship","label":"Calcium signaling is another network connection, with species kept explicit.","description":"DIM increased STIM1 expression and supported store-operated calcium entry in the experimental muscle model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3169279-41ce-5c17-919f-dc7b48f6f6d6","slug":"store-operated-calcium-entry","display_name":"Store-operated calcium entry","entity_type_key":"cellular_process"},"role":"associated_process","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1c781102-56cc-59b2-a200-295a37866f7f","slug":"mouse-stim1","display_name":"Mouse stromal interaction molecule 1 / Stim1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/42308990.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\", \"start_char\": 0, \"end_char\": 2803, \"text_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dexamethasone atrophy and aging-model experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"DIM in experimental atrophy/aging models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"2026 preclinical study, not a human sarcopenia trial. 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(2026). https://pubmed.ncbi.nlm.nih.gov/42308990/ DOI: 10.1016/j.phymed.2026.158409","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial function and store-operated calcium entry","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eb923910-cb56-5c6d-a5b0-3f987139e503","evidence_kind":"source_excerpt","locator":"Lines 1455-1466","start_line":1455,"end_line":1466,"excerpt":"### dim-mouse-stim1\nDIM increased STIM1 expression and supported store-operated calcium entry in the experimental muscle model.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcium signaling is another network connection, with species kept explicit.\norganism: Mouse muscle, mouse C2C12 myotubes and C. elegans\ntissue_or_cell_type: Mitochondrial function and store-operated calcium entry\nexperimental_model: Dexamethasone atrophy and aging-model experiments\nlimitations: 2026 preclinical study, not a human sarcopenia trial. Mouse STIM1 stays distinct from the human selenium-linked STIM1 record.\nexposure: DIM in experimental atrophy/aging models\nevidence_span: {\"source_cache\": \"artifacts/dim-research/42308990.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\", \"start_char\": 0, \"end_char\": 2803, \"text_sha256\": \"4bd26fd33c370df293346c5680820459a885a7545286d92c9e1c27220d41f2cb\"}\n[dim-p42308990] 3,3'-Diindolylmethane ameliorates muscle atrophy by modulating mitochondrial function and calcium homeostasis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308990/ DOI: 10.1016/j.phymed.2026.158409","model_system":"Dexamethasone atrophy and aging-model experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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