{"id":"e12686c4-0aed-527d-b385-c832563a29d1","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-urinary-loss","predicate":"urinary_loss_differed_by_disease","statement":"Urinary zinc excretion was increased in cirrhosis but not in malabsorption, although both groups had low plasma zinc.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c7d64c1c-48c5-553e-baaf-408e3898a43b","mechanism_event_label":"Similar plasma results did not imply the same route of zinc loss.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"ba201e9d-00fe-506a-b3b8-03f39aba8567","slug":"urinary-zinc-excretion","display_name":"Urinary zinc excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c7d64c1c-48c5-553e-baaf-408e3898a43b","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-urinary-loss-event","event_type":"observed_intervention","label":"Similar plasma results did not imply the same route of zinc loss.","description":"Urinary zinc excretion was increased in cirrhosis but not in malabsorption, although both groups had low plasma zinc.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ba201e9d-00fe-506a-b3b8-03f39aba8567","slug":"urinary-zinc-excretion","display_name":"Urinary zinc excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Zinc exposure and the specifically measured response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/walker1973.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"350425d75c9023c5b9ddb97d734e320b4e07c6fe5b834213defb1adc7cc26b00\", \"utf8_bytes\": 991}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Observational comparison of 19 malabsorption patients, 21 cirrhosis patients, 20 controls and 23 other disease patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Fasting and post-meal plasma samples; disease-group comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlations cannot distinguish dietary shortage from albumin binding, redistribution and disease effects. Plasma measurements are not intracellular zinc thresholds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Similar plasma results did not imply the same route of zinc loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-walker1973] Plasma and urinary zinc in patients with malabsorption syndromes or hepatic cirrhosis. (1973). https://pubmed.ncbi.nlm.nih.gov/4785284/ DOI: 10.1136/gut.14.12.943","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"8692a35a-29dc-5603-bd5b-b6292bcf6fb1","evidence_kind":"source_excerpt","locator":"Lines 1467-1480","start_line":1467,"end_line":1480,"excerpt":"### zn-clin-urinary-loss\nUrinary zinc excretion was increased in cirrhosis but not in malabsorption, although both groups had low plasma zinc.\nCondition category: biomarker_context\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Similar plasma results did not imply the same route of zinc loss.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma and urine\nexperimental_model: Observational comparison of 19 malabsorption patients, 21 cirrhosis patients, 20 controls and 23 other disease patients\nlimitations: Correlations cannot distinguish dietary shortage from albumin binding, redistribution and disease effects. Plasma measurements are not intracellular zinc thresholds.\nexposure: Fasting and post-meal plasma samples; disease-group comparisons.\ncross_nutrient: Zinc exposure and the specifically measured response.\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/walker1973.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"350425d75c9023c5b9ddb97d734e320b4e07c6fe5b834213defb1adc7cc26b00\", \"utf8_bytes\": 991}\n[zn-clin-walker1973] Plasma and urinary zinc in patients with malabsorption syndromes or hepatic cirrhosis. (1973). https://pubmed.ncbi.nlm.nih.gov/4785284/ DOI: 10.1136/gut.14.12.943","model_system":"Observational comparison of 19 malabsorption patients, 21 cirrhosis patients, 20 controls and 23 other disease patients","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-walker1973] Plasma and urinary zinc in patients with malabsorption syndromes or hepatic cirrhosis. (1973). https://pubmed.ncbi.nlm.nih.gov/4785284/ DOI: 10.1136/gut.14.12.943","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}