{"id":"e106cbd5-2bc5-557b-9f17-07790ec0328e","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-heaney-steady-state","predicate":"produces-larger-steady-state-increment-than-d2","statement":"Mean steady-state total 25(OH)D increments were 45 ng/mL with D3 and 24 ng/mL with D2 (P<0.001).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"78600117-8e20-59b5-b673-9ae08196163c","mechanism_event_label":"The later steady blood-level rise also differed between the forms.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"23768316-d34f-5f8e-9aee-af94fd13be8d","slug":"serum-total-25-hydroxyvitamin-d","display_name":"Serum total 25-hydroxyvitamin D concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"78600117-8e20-59b5-b673-9ae08196163c","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-heaney-steady-state-event","event_type":"observed_intervention","label":"The later steady blood-level rise also differed between the forms.","description":"Mean steady-state total 25(OH)D increments were 45 ng/mL with D3 and 24 ng/mL with D2 (P<0.001).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"23768316-d34f-5f8e-9aee-af94fd13be8d","slug":"serum-total-25-hydroxyvitamin-d","display_name":"Serum total 25-hydroxyvitamin D concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-blind randomized D2/D3 comparison in 33 adults; weekly dosing for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D2 or D3 50, 000 IU orally each week for 12 weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This weekly regimen and marker response do not establish a universal conversion factor or superiority for every clinical endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The later steady blood-level rise also differed between the forms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[heaney2011] Vitamin D(3) is more potent than vitamin D(2) in humans. (2011). https://pubmed.ncbi.nlm.nih.gov/21177785/ DOI: 10.1210/jc.2010-2230","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f4c5f1a0-ff09-594b-8a11-680709357c75","evidence_kind":"source_excerpt","locator":"Lines 1314-1325","start_line":1314,"end_line":1325,"excerpt":"### vd-heaney-steady-state\nMean steady-state total 25(OH)D increments were 45 ng/mL with D3 and 24 ng/mL with D2 (P<0.001).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The later steady blood-level rise also differed between the forms.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating measurements\nexperimental_model: Single-blind randomized D2/D3 comparison in 33 adults; weekly dosing for 12 weeks\nlimitations: This weekly regimen and marker response do not establish a universal conversion factor or superiority for every clinical endpoint.\nexposure: D2 or D3 50, 000 IU orally each week for 12 weeks.\ncross_nutrient: false\n[heaney2011] Vitamin D(3) is more potent than vitamin D(2) in humans. 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