{"id":"e0f3d3ff-429d-53c2-9a7b-c2076498ad39","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-rat-scd1","predicate":"increases_expression","statement":"HFCS-55 exposure was associated with increased hepatic Scd1 expression in female rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"5412152e-3db0-5de4-bcbb-fb7248ddbbce","mechanism_event_label":"HFCS-55 exposure was associated with increased hepatic Scd1 expression in female rats.","subject":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"object":{"id":"96c936e1-0140-51e3-83d3-e1440701108c","slug":"rat-scd1","display_name":"Rat stearoyl-CoA desaturase 1 / Scd1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"5412152e-3db0-5de4-bcbb-fb7248ddbbce","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-rat-scd1-event","event_type":"observed_relationship","label":"HFCS-55 exposure was associated with increased hepatic Scd1 expression in female rats.","description":"HFCS-55 exposure was associated with increased hepatic Scd1 expression in female rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"96c936e1-0140-51e3-83d3-e1440701108c","slug":"rat-scd1","display_name":"Rat stearoyl-CoA desaturase 1 / Scd1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"832b1926-18e7-5b76-8dc4-bad8ed234645","slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"13% w/v HFCS-55, sucrose or fructose solution versus water","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Female rats, seven per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Direct HFCS-55 animal evidence","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Hypercaloric animal setting. Expression and fatty-acid composition suggest lipogenesis but are not isotope flux measurements; differences do not establish HFCS superiority/inferiority in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Female rats, seven per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"HFCS-55 exposure was associated with increased hepatic Scd1 expression in female rats.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. (2017). https://pubmed.ncbi.nlm.nih.gov/27768909/ DOI: 10.1016/j.jnutbio.2016.09.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral ad libitum solution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Hepatic lipid and expression endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5885aa79-a279-57df-aee2-09db2abaec8a","evidence_kind":"source_excerpt","locator":"Lines 437-447","start_line":437,"end_line":447,"excerpt":"## hfcs-rat-scd1\nHFCS-55 exposure was associated with increased hepatic Scd1 expression in female rats.\nModel/species: Female rats, seven per group\nTissue: Hepatic lipid and expression endpoints\nExposure: 13% w/v HFCS-55, sucrose or fructose solution versus water\nRoute: Oral ad libitum solution\nDuration: 8 weeks\nExposure scope: Direct HFCS-55 animal evidence\nLimits: Hypercaloric animal setting. Expression and fatty-acid composition suggest lipogenesis but are not isotope flux measurements; differences do not establish HFCS superiority/inferiority in humans.\nReference: High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. (2017). https://pubmed.ncbi.nlm.nih.gov/27768909/ DOI: 10.1016/j.jnutbio.2016.09.010\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"Female rats, seven per group","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}