{"id":"e0607f82-d254-5a96-9398-79b8996dbcdf","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-myeloma-combination","predicate":"enhances_in_combination","statement":"Combinations of mangiferin with tested anticancer drugs reduced myeloma-cell viability more than the agents separately.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"16417b9a-766b-5631-82b0-ddd7c95682e5","mechanism_event_label":"A combination effect was observed in cell culture.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"539f8b00-1ba4-590d-b4c9-082e2cc41c88","slug":"human-myeloma-drug-cytotoxicity","display_name":"Anticancer-drug cytotoxicity in human myeloma-cell combinations","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"16417b9a-766b-5631-82b0-ddd7c95682e5","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-myeloma-combination-event","event_type":"biochemical_relationship","label":"A combination effect was observed in cell culture.","description":"Combinations of mangiferin with tested anticancer drugs reduced myeloma-cell viability more than the agents separately.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"539f8b00-1ba4-590d-b4c9-082e2cc41c88","slug":"human-myeloma-drug-cytotoxicity","display_name":"Anticancer-drug cytotoxicity in human myeloma-cell combinations","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/27035859.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"018c08f93a5101b1a7fbafdbc99357f6d4baa9eed19711ff63e6c7cd3d3ec13e\", \"start_char\": 0, \"end_char\": 1327, \"text_sha256\": \"018c08f93a5101b1a7fbafdbc99357f6d4baa9eed19711ff63e6c7cd3d3ec13e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Anticancer drug-combination experiments in myeloma cell lines","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin plus conventional anticancer agents; individual regimen not assigned from abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell viability and apoptosis findings do not establish clinical combination safety, benefit or formal pharmacologic synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A combination effect was observed in cell culture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p27035859] Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway. (2016). https://pubmed.ncbi.nlm.nih.gov/27035859/ DOI: 10.3892/ijo.2016.3470","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Multiple-myeloma cell lines","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b1d5690f-628b-5604-b99e-df2bad8989f0","evidence_kind":"source_excerpt","locator":"Lines 1355-1366","start_line":1355,"end_line":1366,"excerpt":"### mangiferin-myeloma-combination\nCombinations of mangiferin with tested anticancer drugs reduced myeloma-cell viability more than the agents separately.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A combination effect was observed in cell culture.\norganism: Homo sapiens\ntissue_or_cell_type: Multiple-myeloma cell lines\nexperimental_model: Anticancer drug-combination experiments in myeloma cell lines\nlimitations: Cell viability and apoptosis findings do not establish clinical combination safety, benefit or formal pharmacologic synergy.\nexposure: Mangiferin plus conventional anticancer agents; individual regimen not assigned from abstract\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/27035859.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"018c08f93a5101b1a7fbafdbc99357f6d4baa9eed19711ff63e6c7cd3d3ec13e\", \"start_char\": 0, \"end_char\": 1327, \"text_sha256\": \"018c08f93a5101b1a7fbafdbc99357f6d4baa9eed19711ff63e6c7cd3d3ec13e\"}\n[mangiferin-p27035859] Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway. 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