{"id":"e05a8537-3de1-527f-a44b-be9042c58edd","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-sasp-cd38","predicate":"induces","statement":"Senescent-cell-associated inflammatory signals promoted CD38 expression; reducing senescent-cell burden partially restored NAD+ in the reported mouse experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4e30428c-d2cc-5868-b5cf-25c69f39ecba","mechanism_event_label":"Signals from one cell population can change NAD availability in another.","subject":{"id":"3b38fbf1-e3c9-52ae-b2ae-aec56a66e465","slug":"mouse-senescent-cell-secretory-factors","display_name":"Secretory factors from senescent mouse-cell models","entity_type_key":"cellular_process"},"object":{"id":"77c40786-fc17-5efb-887f-52a76163a9ba","slug":"mouse-cd38","display_name":"Mouse CD38","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"4e30428c-d2cc-5868-b5cf-25c69f39ecba","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-sasp-cd38-event","event_type":"observed_relationship","label":"Signals from one cell population can change NAD availability in another.","description":"Senescent-cell-associated inflammatory signals promoted CD38 expression; reducing senescent-cell burden partially restored NAD+ in the reported mouse experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3b38fbf1-e3c9-52ae-b2ae-aec56a66e465","slug":"mouse-senescent-cell-secretory-factors","display_name":"Secretory factors from senescent mouse-cell models","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"77c40786-fc17-5efb-887f-52a76163a9ba","slug":"mouse-cd38","display_name":"Mouse CD38","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Senescent-cell conditioned media and mouse interventions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Partial rescue supports a contributing mechanism, not a single cause of every age-associated NAD decline.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Signals from one cell population can change NAD availability in another.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33199925/ · DOI 10.1038/s42255-020-00298-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"354b069a-ae7d-5c25-9626-147c3646de1f","evidence_kind":"source_excerpt","locator":"Lines 108-114","start_line":108,"end_line":114,"excerpt":"## nad-plus-sasp-cd38\nSignals from one cell population can change NAD availability in another.\nSenescent-cell-associated inflammatory signals promoted CD38 expression; reducing senescent-cell burden partially restored NAD+ in the reported mouse experiments.\nModel: Senescent-cell conditioned media and mouse interventions.\nLimitations: Partial rescue supports a contributing mechanism, not a single cause of every age-associated NAD decline.\nEvidence access: Primary full text\nCD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33199925/ · DOI 10.1038/s42255-020-00298-z","model_system":"Senescent-cell conditioned media and mouse interventions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f59aa302-d463-5462-876f-e21e64861eac","stable_key":"import-8c946991-97f0-55ee-8df0-00e67621962f","title":"NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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