{"id":"e03474fd-fd17-5216-9c4a-62df7daf4f07","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:mouse-hadha-function-rescue","predicate":"reduces","statement":"HADHA overexpression improved the reported diastolic phenotype of Dlat-transgenic mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a2bc3fc8-6cd1-5b95-8931-8e9045a0a234","mechanism_event_label":"mouse hadha function rescue","subject":{"id":"9d31720a-fb23-52b9-b129-0d69357ab8ef","slug":"mouse-hadha-overexpression","display_name":"Cardiomyocyte-targeted mouse HADHA overexpression","entity_type_key":"protein_state"},"object":{"id":"2ece61c9-ca48-516e-b637-db426cde0da3","slug":"mouse-cardiac-diastolic-impairment","display_name":"Mouse cardiac diastolic impairment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a2bc3fc8-6cd1-5b95-8931-8e9045a0a234","stable_key":"c156003d-8cdf-5259-8561-9803795ecc82:mouse-hadha-function-rescue","event_type":"reduces","label":"mouse hadha function rescue","description":"Model-specific finding; read linked claim context and source-access tier.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9d31720a-fb23-52b9-b129-0d69357ab8ef","slug":"mouse-hadha-overexpression","display_name":"Cardiomyocyte-targeted mouse HADHA overexpression","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ece61c9-ca48-516e-b637-db426cde0da3","slug":"mouse-cardiac-diastolic-impairment","display_name":"Mouse cardiac diastolic impairment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"access_level","value_text":"full_text_and_supplement_review","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"compartment","value_text":"Cardiac tissue / mitochondria","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Tamoxifen-induced genetic overexpression; vector/induction dose not established in this extraction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Transgenic induction age and observation interval differ across passages; exact interval unresolved","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"mouse-cardiac-diastolic-impairment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Supplementary Figure S22","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional cardiac Dlat-transgenic mice; HADHA AAV9 rescue where stated","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"mouse-hadha-overexpression","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single primary study; not independently replicated here. Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. 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Cardiac and recombinant findings do not establish pulmonary endothelial, viral-sepsis or ARDS effects. Mouse overexpression result; K728 was not mutated in vivo.\nprimary_locator: [{\"cache\": \"artifacts/dlat-curation/heart-blocks.json\", \"block_index\": 52, \"text_sha256\": \"74297778077d895148e1cc0c9819297c22c274b0ec6fdce0483ce8ba94ab58b4\", \"xml_element_id\": \"Par21\"}]\nplain_language: HADHA overexpression improved the reported diastolic phenotype of Dlat-transgenic mice.\nsample_size: 8 per group","model_system":"Conditional cardiac Dlat-transgenic mice; HADHA AAV9 rescue where stated","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Quotation is the authored curation, not original publisher wording. Exact primary locators and access limits retained in contexts.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ee72956d-4fd4-58d3-9a94-e173bb1e3282","stable_key":"import-c156003d-8cdf-5259-8561-9803795ecc82","title":"DLAT: cardiac fatty-acid oxidation and mitochondrial glutathione evidence","document_type":"imported_text","citation_label":"AI-assisted two-paper curation, 2026-09-20. Cardiac full-text/supplement review; CRC abstract only. No pulmonary endothelial validation.","file_path":"","sha256":"159e5472c8b1d104625f9c648dc9ee24dcd5fe102109fd960bba50e9ba9de954","revision_id":"5ca6b1f1-fd75-5f8d-ba2b-0215fbf387c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}