{"id":"e012d4db-a792-57eb-b8e9-31366b6be1cc","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-clock-person-specific","predicate":"modulates","statement":"Lithium effects on circadian rhythms varied across bipolar patient-derived fibroblasts; longer-period cells had muted responses.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"918c78f5-be0b-5f49-a583-d251cd0522ff","mechanism_event_label":"Cells from different people did not respond identically.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"d4904783-4c4a-5116-8c41-212dff8543fc","slug":"human-fibroblast-circadian-response","display_name":"Human fibroblast circadian response to lithium","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"918c78f5-be0b-5f49-a583-d251cd0522ff","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-clock-person-specific-event","event_type":"observed_relationship","label":"Cells from different people did not respond identically.","description":"Lithium effects on circadian rhythms varied across bipolar patient-derived fibroblasts; longer-period cells had muted responses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d4904783-4c4a-5116-8c41-212dff8543fc","slug":"human-fibroblast-circadian-response","display_name":"Human fibroblast circadian response to lithium","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"39 bipolar donors and 23 controls; ex-vivo clock measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a validated clinical test for choosing treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Cells from different people did not respond identically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32404948/ · DOI 10.1038/s41380-020-0769-6","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7d2804af-6551-5a91-8295-39d384a00c72","evidence_kind":"source_excerpt","locator":"Lines 248-254","start_line":248,"end_line":254,"excerpt":"## lithium-clock-person-specific\nCells from different people did not respond identically.\nLithium effects on circadian rhythms varied across bipolar patient-derived fibroblasts; longer-period cells had muted responses.\nModel: 39 bipolar donors and 23 controls; ex-vivo clock measurements.\nLimitations: Not a validated clinical test for choosing treatment.\nEvidence access: Primary full text\nPatient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. · 2021 · https://pubmed.ncbi.nlm.nih.gov/32404948/ · DOI 10.1038/s41380-020-0769-6","model_system":"39 bipolar donors and 23 controls; ex-vivo clock measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}