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topical membership is not evidence of a direct dietary effect.\nplain_language: Receptor-bearing vesicles reached brain tissue in this experiment.\norganism: Mus musculus receiving human-FOLR1-associated exosomes\ntissue_or_cell_type: Brain parenchyma\nexperimental_model: Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections\nlimitations: Injection bypasses entry from blood; does not prove all brain folate follows this route.\nexposure: Intraventricular exosome administration\n[grapp2013] Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma (2013). https://pubmed.ncbi.nlm.nih.gov/23828504/ DOI: 10.1038/ncomms3123","model_system":"Human FOLR1 in rat choroid-plexus cells, human CSF, mouse injections","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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