{"id":"dfe4e375-7d31-5af5-86ba-4520618992c1","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-animal-insulin","predicate":"increases_tested","statement":"The study reported increased insulin secretion with 0.15% aspartame in mice and monkeys.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fd3d11ff-69d1-5dd5-893c-ae5f12fc1b8c","mechanism_event_label":"A neural or hormonal route can differ from metabolite toxicity.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"83a38de1-2c10-5094-b256-3ddb64706b51","slug":"mouse-aspartame-insulin-secretion","display_name":"Mouse insulin response to aspartame","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fd3d11ff-69d1-5dd5-893c-ae5f12fc1b8c","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-animal-insulin-event","event_type":"observed_relationship","label":"A neural or hormonal route can differ from metabolite toxicity.","description":"The study reported increased insulin secretion with 0.15% aspartame in mice and monkeys.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"83a38de1-2c10-5094-b256-3ddb64706b51","slug":"mouse-aspartame-insulin-secretion","display_name":"Mouse insulin response to aspartame","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2974f82-32d7-5708-80d7-5c16388d272d","slug":"monkey-aspartame-insulin-response","display_name":"Monkey insulin response to aspartame","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Animal feeding experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Exact duration and systemic dose not supplied by accessed abstract; do not infer ordinary human intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A neural or hormonal route can differ from metabolite toxicity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39978336/ · DOI 10.1016/j.cmet.2025.01.006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d125fcde-a2f0-5e85-a9a9-61783835fb57","evidence_kind":"source_excerpt","locator":"Lines 242-248","start_line":242,"end_line":248,"excerpt":"## aspartame-animal-insulin\nA neural or hormonal route can differ from metabolite toxicity.\nThe study reported increased insulin secretion with 0.15% aspartame in mice and monkeys.\nModel: Animal feeding experiments.\nLimitations: Exact duration and systemic dose not supplied by accessed abstract; do not infer ordinary human intake.\nEvidence access: Primary abstract\nSweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39978336/ · DOI 10.1016/j.cmet.2025.01.006","model_system":"Animal feeding experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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