{"id":"df806078-edc7-5534-8c5f-8de4e5bfa8de","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-zinc-supplementation-liver","predicate":"reduces","statement":"Zinc supplementation prevented alcoholic liver injury in mice through attenuation of oxidative stress.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b0b2eb5f-f9c4-56cd-8803-7ddfc74b46d7","mechanism_event_label":"Giving zinc back prevented the liver damage in this model.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"b2dd390a-349b-581f-8224-9da1206e4e2a","slug":"alcoholic-liver-injury","display_name":"Alcoholic liver injury","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b0b2eb5f-f9c4-56cd-8803-7ddfc74b46d7","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-zinc-supplementation-liver-event","event_type":"biochemical_relationship","label":"Giving zinc back prevented the liver damage in this model.","description":"Zinc supplementation prevented alcoholic liver injury in mice through attenuation of oxidative stress.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c21da023-1ba9-59bb-948e-da43498dc9d4","slug":"hepatic-ros","display_name":"Hepatic reactive oxygen species production","entity_type_key":"cellular_process"},"role":"reduced_process","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b2dd390a-349b-581f-8224-9da1206e4e2a","slug":"alcoholic-liver-injury","display_name":"Alcoholic liver injury","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/15920153.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c25d41f17a1af981cc13b2e85ff6017ea8d48817b1fe8e4f22f8a3126e1af244\", \"start_char\": 0, \"end_char\": 1654, \"text_sha256\": \"c25d41f17a1af981cc13b2e85ff6017ea8d48817b1fe8e4f22f8a3126e1af244\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Alcohol-fed mice given zinc supplementation with oxidative stress measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic alcohol feeding with and without zinc supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A repletion experiment, which is stronger than an association. It is a mouse prevention model, not a treatment trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Giving zinc back prevented the liver damage in this model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p15920153] Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. (2005). https://pubmed.ncbi.nlm.nih.gov/15920153/ DOI: 10.1016/s0002-9440(10)62478-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"805c63dc-c494-5537-a228-2d1e4fb76e13","evidence_kind":"source_excerpt","locator":"Lines 787-798","start_line":787,"end_line":798,"excerpt":"### alcohol-zinc-supplementation-liver\nZinc supplementation prevented alcoholic liver injury in mice through attenuation of oxidative stress.\nCondition category: nutrient_deficiency\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: Giving zinc back prevented the liver damage in this model.\norganism: Mouse\ntissue_or_cell_type: Liver\nexperimental_model: Alcohol-fed mice given zinc supplementation with oxidative stress measurement\nlimitations: A repletion experiment, which is stronger than an association. It is a mouse prevention model, not a treatment trial.\nexposure: Chronic alcohol feeding with and without zinc supplementation\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/15920153.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c25d41f17a1af981cc13b2e85ff6017ea8d48817b1fe8e4f22f8a3126e1af244\", \"start_char\": 0, \"end_char\": 1654, \"text_sha256\": \"c25d41f17a1af981cc13b2e85ff6017ea8d48817b1fe8e4f22f8a3126e1af244\"}\n[alcohol-p15920153] Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. (2005). https://pubmed.ncbi.nlm.nih.gov/15920153/ DOI: 10.1016/s0002-9440(10)62478-9","model_system":"Alcohol-fed mice given zinc supplementation with oxidative stress measurement","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [alcohol-p15920153] Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. (2005). https://pubmed.ncbi.nlm.nih.gov/15920153/ DOI: 10.1016/s0002-9440(10)62478-9","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4b310db0-1387-548c-9e3d-6d2ed634b2cd","stable_key":"import-fcc4fa9c-4dc8-5566-b780-1a486c4d3e72","title":"Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"cb7e8dc390e8bf302cd5e230cadff6ce9847b4aad8a3691a308964d93ba59a85","revision_id":"4b344e1e-4129-579c-a058-50262b03f9a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}