{"id":"df5370d0-5a65-5003-85d0-4f17a94ca9af","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-nmn-muscle-versus-blood","predicate":"has_compartment_specific_response","statement":"In 25 postmenopausal women with prediabetes and overweight/obesity, 250 mg/day NMN for ten weeks increased basal PBMC NAD but did not increase measured muscle NAD; muscle NAD-related catabolites increased.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"da30856b-9d3a-5923-898b-4b3d894cfb32","mechanism_event_label":"A blood-cell response did not mean measured muscle NAD rose.","subject":{"id":"d1c59139-db61-5fa0-a25d-40c3e625152e","slug":"nmn","display_name":"NMN","entity_type_key":"small_molecule"},"object":{"id":"826d060f-7c48-5f10-af28-a016c03a52b0","slug":"skeletal-muscle-nad-plus-content","display_name":"Skeletal muscle NAD+ content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"da30856b-9d3a-5923-898b-4b3d894cfb32","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-nmn-muscle-versus-blood-event","event_type":"observed_relationship","label":"A blood-cell response did not mean measured muscle NAD rose.","description":"In 25 postmenopausal women with prediabetes and overweight/obesity, 250 mg/day NMN for ten weeks increased basal PBMC NAD but did not increase measured muscle NAD; muscle NAD-related catabolites increased.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d1c59139-db61-5fa0-a25d-40c3e625152e","slug":"nmn","display_name":"NMN","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"826d060f-7c48-5f10-af28-a016c03a52b0","slug":"skeletal-muscle-nad-plus-content","display_name":"Skeletal muscle NAD+ content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5d85872f-c88c-5e8b-a2c6-99a1eb636431","slug":"pbmc-nad-plus-content","display_name":"PBMC NAD+ content","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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