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(2022). https://pubmed.ncbi.nlm.nih.gov/35740030/ DOI: 10.3390/antiox11061132","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"RPE injury model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e4f7ba7e-d7e3-5fcf-990c-51394259e3ae","evidence_kind":"source_excerpt","locator":"Lines 925-936","start_line":925,"end_line":936,"excerpt":"### zeaxanthin-c-e-z-protection\nCombined zeaxanthin and alpha-tocopherol raised viability from about 26% to 63% in the tested model.\nCondition category: normal\nnutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The pair protected cells against this defined light challenge.\norganism: Human ARPE-19 cells and unsaturated liposomes\ntissue_or_cell_type: RPE injury model\nexperimental_model: Retinaldehyde-liposome photosensitization with cells\nlimitations: Bath concentrations and irradiation are not oral doses or established human safety limits. Combination conditions and localization matter.\nexposure: 4 micromolar zeaxanthin, 80 micromolar alpha-tocopherol; 0.5–2 mM ascorbate\nevidence_span: {\"source_cache\": \"artifacts/zeaxanthin-research/35740030.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6c66a3183f1b2cc985ad22d5350f53aaeaf65b2519e89ddc13e0460a035903e8\", \"start_char\": 0, \"end_char\": 1784, \"text_sha256\": \"6c66a3183f1b2cc985ad22d5350f53aaeaf65b2519e89ddc13e0460a035903e8\"}\n[zeaxanthin-p35740030] Is There an Optimal Combination of AREDS2 Antioxidants Zeaxanthin, Vitamin E and Vitamin C on Light-Induced Toxicity of Vitamin A Aldehyde to the Retina? 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