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Solubility prevented a precise association constant for mebendazole itself.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mebendazole","display_name":"Mebendazole","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Nematode and pig","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In the gut of the worm, the drug wipes out the protein it is supposed to act on.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mbz-p7335116] Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic nematodes. 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Solubility prevented a precise association constant for mebendazole itself.\nexposure: In vitro incubation of Ascaris suum with 10 micromolar mebendazole, with tubulin partially purified from the intestine\nevidence_span: {\"source_cache\": \"artifacts/mebendazole-research/7335116.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"358adb37f881bf9fc64cf4cea24ce690792e958df702a705b2addda3295ad144\", \"start_char\": 0, \"end_char\": 1621, \"text_sha256\": \"358adb37f881bf9fc64cf4cea24ce690792e958df702a705b2addda3295ad144\"}\n[mbz-p7335116] Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic nematodes. 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