{"id":"df43143e-f9ca-5496-b7a8-a9c34f129322","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-s-rat-pk","predicate":"delivers","statement":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine S gave 15.13% estimated absolute bioavailability and distributed erinacine S to brain and multiple peripheral organs.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"07245d4d-a314-539e-a9ed-35cf039db909","mechanism_event_label":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine S gave 15.13% estimated absolute bioavailability and distributed erinacine S to brain and multiple peripheral organs.","subject":{"id":"f63dc698-ae0f-5ac8-b16d-862450c23b5e","slug":"erinacine-s-enriched-mycelial-extract","display_name":"Erinacine-S-containing Hericium mycelial extract","entity_type_key":"botanical"},"object":{"id":"150d76c7-72b1-5c50-a332-c6f7e78d32bc","slug":"erinacine-s","display_name":"Erinacine S","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"07245d4d-a314-539e-a9ed-35cf039db909","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-s-rat-pk-event","event_type":"observed_relationship","label":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine S gave 15.13% estimated absolute bioavailability and distributed erinacine S to brain and multiple peripheral organs.","description":"In rats, oral mycelial extract equivalent to 50 mg/kg erinacine S gave 15.13% estimated absolute bioavailability and distributed erinacine S to brain and multiple peripheral organs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f63dc698-ae0f-5ac8-b16d-862450c23b5e","slug":"erinacine-s-enriched-mycelial-extract","display_name":"Erinacine-S-containing Hericium mycelial extract","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"150d76c7-72b1-5c50-a332-c6f7e78d32bc","slug":"erinacine-s","display_name":"Erinacine S","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Oral extract equivalent to 50 mg/kg erinacine S; IV 5 mg/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"24-hour excretion and tissue sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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