{"id":"dee49e60-7766-5f78-989b-bb9b1cc0a2c8","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-rag-rescue","predicate":"activated_form_rescues","statement":"Expression of constitutively active RAGA(Q66L) was used to restore mTOR signaling and growth-associated function downstream of taurine-uptake loss in mouse leukemia cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc04384c-5fbc-546f-9bc8-f58ea8ed1d8f","mechanism_event_label":"A downstream rescue tested the signaling chain.","subject":{"id":"ed493ed7-d78c-5509-820a-cb32dd5a1327","slug":"mouse-rraga","display_name":"Mouse Ras-related GTP-binding protein A / Rraga","entity_type_key":"protein"},"object":{"id":"6de453cd-ee87-5a7d-9fd1-d7e4d7d46c0d","slug":"mouse-taut-mtor-glycolysis","display_name":"mTOR signaling and glycolysis in mouse taurine-dependent leukemia cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cc04384c-5fbc-546f-9bc8-f58ea8ed1d8f","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-leukemia-rag-rescue-event","event_type":"observed_relationship","label":"A downstream rescue tested the signaling chain.","description":"Expression of constitutively active RAGA(Q66L) was used to restore mTOR signaling and growth-associated function downstream of taurine-uptake loss in mouse leukemia cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ed493ed7-d78c-5509-820a-cb32dd5a1327","slug":"mouse-rraga","display_name":"Mouse Ras-related GTP-binding protein A / Rraga","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6de453cd-ee87-5a7d-9fd1-d7e4d7d46c0d","slug":"mouse-taut-mtor-glycolysis","display_name":"mTOR signaling and glycolysis in mouse taurine-dependent leukemia cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2bf56761-aaca-5d23-aadc-5d1f80178ec4","slug":"mouse-mtor","display_name":"Mouse mechanistic target of rapamycin / Mtor","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"97bfec84-f327-5208-8983-71138dd03b45","slug":"mouse-slc6a6","display_name":"Mouse taurine transporter / Slc6a6","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, Figure 5p–s and associated results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse leukemia expression-rescue experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rescue does not identify taurine as a direct physical ligand of RAGA.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; 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