{"id":"de778c96-770f-5708-b7dd-7b0954f985fa","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-colon-ros-ranking","predicate":"was_least_effective_tested_derivative_for","statement":"Nasunin had the smallest ROS-reduction effect among the tested delphinidin derivatives.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e3da3335-58a0-5e63-9532-fa6100445de4","mechanism_event_label":"An acylated pigment can rank differently inside cells than in solution.","subject":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"object":{"id":"892f07aa-be61-5b10-8b42-fba82999211c","slug":"colon-cell-ros-readout","display_name":"ROS readout in HT-29 and HCT-116 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e3da3335-58a0-5e63-9532-fa6100445de4","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-colon-ros-ranking-event","event_type":"biochemical_relationship","label":"An acylated pigment can rank differently inside cells than in solution.","description":"Nasunin had the smallest ROS-reduction effect among the tested delphinidin derivatives.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"892f07aa-be61-5b10-8b42-fba82999211c","slug":"colon-cell-ros-readout","display_name":"ROS readout in HT-29 and HCT-116 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/25442541.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7\", \"start_char\": 0, \"end_char\": 1299, \"text_sha256\": \"14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Comparative anthocyanin exposure in cultured colon cancer lines","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nasunin and differently glycosylated delphinidin derivatives; quantitative regimens not specified in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary experiments are described despite an additional Review index tag. 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Protein association does not establish GSR-mediated causality; these are cancer cells, not normal colon tissue or patients.\nexposure: Nasunin and differently glycosylated delphinidin derivatives; quantitative regimens not specified in indexed abstract\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/25442541.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7\", \"start_char\": 0, \"end_char\": 1299, \"text_sha256\": \"14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7\"}\n[nasunin-p25442541] Effect of glycosylation patterns of Chinese eggplant anthocyanins and other derivatives on antioxidant effectiveness in human colon cell lines. 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