{"id":"de763849-f3f1-54cb-a6b7-710848127578","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-comt-human","predicate":"increases_measured_activity","statement":"After 750 mg EGCG in 24 volunteers, erythrocyte COMT activity increased by 24% at two hours rather than decreasing.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"2650e6b3-4be5-5ca4-bdad-5e11afcd2f5d","mechanism_event_label":"The measured human red-cell result did not match a simple inhibition prediction.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"180187b7-ea6d-5231-84b9-172d15668534","slug":"erythrocyte-comt-activity","display_name":"Human erythrocyte COMT activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2650e6b3-4be5-5ca4-bdad-5e11afcd2f5d","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-comt-human-event","event_type":"observed_relationship","label":"The measured human red-cell result did not match a simple inhibition prediction.","description":"After 750 mg EGCG in 24 volunteers, erythrocyte COMT activity increased by 24% at two hours rather than decreasing.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"180187b7-ea6d-5231-84b9-172d15668534","slug":"erythrocyte-comt-activity","display_name":"Human erythrocyte COMT activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"936e1fd4-e862-5e32-b7dc-35b946294e43","slug":"comt","display_name":"Human catechol O-methyltransferase / COMT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Single exposure; 14 women and 10 men; COMT genotype assessment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Red-cell activity at one time point is not a measurement of brain or liver COMT. No general catecholamine or fat-burning claim follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The measured human red-cell result did not match a simple inhibition prediction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24972245/ · DOI 10.1016/j.ejphar.2014.06.014","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a8e0ddde-10b3-5147-a3ba-23a9dd595eef","evidence_kind":"source_excerpt","locator":"Lines 180-186","start_line":180,"end_line":186,"excerpt":"## egcg-comt-human\nThe measured human red-cell result did not match a simple inhibition prediction.\nAfter 750 mg EGCG in 24 volunteers, erythrocyte COMT activity increased by 24% at two hours rather than decreasing.\nModel: Single exposure; 14 women and 10 men; COMT genotype assessment.\nLimitations: Red-cell activity at one time point is not a measurement of brain or liver COMT. No general catecholamine or fat-burning claim follows.\nEvidence access: primary abstract.\nThe activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24972245/ · DOI 10.1016/j.ejphar.2014.06.014","model_system":"Single exposure; 14 women and 10 men; COMT genotype assessment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}