{"id":"de5af84a-5273-5175-8eb6-8452165daf74","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-tocotrienol-synergy","predicate":"coencapsulation_enhances_scavenging_of","statement":"Liposomes containing astaxanthin plus alpha- or gamma-tocotrienol showed radical-scavenging activity greater than the calculated additive activity in the reported singlet-oxygen/hydroxyl-radical assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"797656d5-d333-5b77-8801-9b49315aadfa","mechanism_event_label":"Some vitamin E forms worked together with astaxanthin in this test system.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"797656d5-d333-5b77-8801-9b49315aadfa","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-tocotrienol-synergy-event","event_type":"observed_relationship","label":"Some vitamin E forms worked together with astaxanthin in this test system.","description":"Liposomes containing astaxanthin plus alpha- or gamma-tocotrienol showed radical-scavenging activity greater than the calculated additive activity in the reported singlet-oxygen/hydroxyl-radical assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"45597684-ead7-5ebe-975a-ac3bc714e22c","slug":"alpha-tocotrienol","display_name":"Alpha-tocotrienol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"27fc7c66-efe2-57b6-988b-560bb242182d","slug":"gamma-tocotrienol","display_name":"Gamma-tocotrienol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free co-encapsulated liposomes; matched single-agent comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measured assay synergy is not demonstrated oral or clinical synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Some vitamin E forms worked together with astaxanthin in this test system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27698536/ · DOI 10.3164/jcbn.15-153","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3ed4c494-857b-5e1c-adff-310e4f3211fd","evidence_kind":"source_excerpt","locator":"Lines 190-196","start_line":190,"end_line":196,"excerpt":"## astaxanthin-tocotrienol-synergy\nSome vitamin E forms worked together with astaxanthin in this test system.\nLiposomes containing astaxanthin plus alpha- or gamma-tocotrienol showed radical-scavenging activity greater than the calculated additive activity in the reported singlet-oxygen/hydroxyl-radical assays.\nModel: Cell-free co-encapsulated liposomes; matched single-agent comparisons.\nLimitations: Measured assay synergy is not demonstrated oral or clinical synergy.\nEvidence access: Primary abstract\nSynergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27698536/ · DOI 10.3164/jcbn.15-153","model_system":"Cell-free co-encapsulated liposomes; matched single-agent comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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