{"id":"de56e69c-2758-5de1-8d60-e0994afc5567","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-mac-tel-association","predicate":"is_inversely_associated_with","statement":"Among 125 MacTel type 2 patients without pathogenic SPT variants and 94 controls, circulating serine was lower and deoxysphingolipids higher in the patient group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1f9f82ee-f28d-51dd-8ac0-67b334601d1d","mechanism_event_label":"A low measured amino-acid pool was associated with an abnormal lipid signature.","subject":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"object":{"id":"4d9df16d-24fa-5dc5-ab2a-2369a6a0399d","slug":"1-deoxysphingolipids","display_name":"1-Deoxysphingolipids","entity_type_key":"lipid"},"evidence_count":1,"mechanism_event":{"id":"1f9f82ee-f28d-51dd-8ac0-67b334601d1d","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-mac-tel-association-event","event_type":"observed_relationship","label":"A low measured amino-acid pool was associated with an abnormal lipid signature.","description":"Among 125 MacTel type 2 patients without pathogenic SPT variants and 94 controls, circulating serine was lower and deoxysphingolipids higher in the patient group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4d9df16d-24fa-5dc5-ab2a-2369a6a0399d","slug":"1-deoxysphingolipids","display_name":"1-Deoxysphingolipids","entity_type_key":"lipid"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human case-control metabolomics; serine 20.6% lower and deoxysphingolipids 84.2% higher.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not establish a dietary cause, universal threshold or supplementation benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A low measured amino-acid pool was associated with an abnormal lipid signature.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31509666/ · DOI 10.1056/NEJMoa1815111","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5b9d8a54-4eb0-5d48-80e4-0af326d4a00a","evidence_kind":"source_excerpt","locator":"Lines 270-276","start_line":270,"end_line":276,"excerpt":"## l-serine-mac-tel-association\nA low measured amino-acid pool was associated with an abnormal lipid signature.\nAmong 125 MacTel type 2 patients without pathogenic SPT variants and 94 controls, circulating serine was lower and deoxysphingolipids higher in the patient group.\nModel: Human case-control metabolomics; serine 20.6% lower and deoxysphingolipids 84.2% higher.\nLimitations: Association does not establish a dietary cause, universal threshold or supplementation benefit.\nEvidence access: Primary abstract\nSerine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31509666/ · DOI 10.1056/NEJMoa1815111","model_system":"Human case-control metabolomics; serine 20.6% lower and deoxysphingolipids 84.2% higher.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70bcf57a-36bb-563f-9073-2d616e5f155a","stable_key":"import-649e861b-265a-5912-bc36-3a73e53ef892","title":"L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"22a750ce2b94f8607268c58322c48c4f0468f403b72a4008307538a6e5ff86d5","revision_id":"c1d6a7e1-9558-5bc6-9e3b-7080c26d3dbc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}